The Effect of Polymerization Techniques on the Creation of Molecularly Imprinted Polymer Sensors and Their Application on Pharmaceutical Compounds.

IF 4.2 2区 化学 Q1 CHEMISTRY, ANALYTICAL
Abdullah Al Faysal, S Irem Kaya, Ahmet Cetinkaya, Sibel A Ozkan, Ayşegül Gölcü
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引用次数: 0

Abstract

Molecularly imprinted polymers (MIPs) have become more prevalent in fabricating sensor applications, particularly in medicine, pharmaceuticals, food quality monitoring, and the environment. The ease of their preparation, adaptability of templates, superior affinity and specificity, improved stability, and the possibility for downsizing are only a few benefits of these sensors. Moreover, from a medical perspective, monitoring therapeutic medications and determining pharmaceutical compounds in their pharmaceutical forms and biological systems is very important. Additionally, because medications are hazardous to the environment, effective, quick, and affordable determination in the surrounding environment is of major importance. Concerning a variety of performance criteria, including sensitivity, specificity, low detection limits, and affordability, MIP sensors outperform other published technologies for analyzing pharmaceutical drugs. MIP sensors have, therefore, been widely used as one of the most crucial techniques for analyzing pharmaceuticals. The first part of this review provides a detailed explanation of the many polymerization techniques that were employed to create high-performing MIP sensors. In the subsequent section of the review, the utilization of MIP-based sensors for quantifying the drugs in their pharmaceutical preparation, biological specimens, and environmental samples are covered in depth. Finally, a critical evaluation of the potential future research paths for MIP-based sensors clarifies the use of MIP in pharmaceutical fields.

聚合技术对创建分子印迹聚合物传感器的影响及其在药物化合物中的应用。
分子印迹聚合物(MIPs)在制造传感器应用中越来越普遍,尤其是在医学、制药、食品质量监测和环境领域。分子印迹聚合物易于制备、模板适应性强、亲和性和特异性高、稳定性好,而且可以缩小尺寸,这些仅仅是这些传感器的几个优点。此外,从医学角度来看,监测治疗药物并确定药物形式和生物系统中的药物化合物非常重要。此外,由于药物对环境有害,因此在周围环境中进行有效、快速和经济的测定也非常重要。就灵敏度、特异性、低检测限和经济性等各种性能标准而言,MIP 传感器在分析药物方面优于其他已公布的技术。因此,MIP 传感器已被广泛用作分析药物的最关键技术之一。本综述的第一部分详细介绍了用于制造高性能 MIP 传感器的多种聚合技术。在综述的后续部分,深入介绍了如何利用 MIP 传感器对药物制剂、生物样本和环境样本中的药物进行定量分析。最后,对基于 MIP 的传感器未来可能的研究方向进行了批判性评估,明确了 MIP 在制药领域的应用。
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来源期刊
CiteScore
12.00
自引率
4.00%
发文量
137
审稿时长
6 months
期刊介绍: Critical Reviews in Analytical Chemistry continues to be a dependable resource for both the expert and the student by providing in-depth, scholarly, insightful reviews of important topics within the discipline of analytical chemistry and related measurement sciences. The journal exclusively publishes review articles that illuminate the underlying science, that evaluate the field''s status by putting recent developments into proper perspective and context, and that speculate on possible future developments. A limited number of articles are of a "tutorial" format written by experts for scientists seeking introduction or clarification in a new area. This journal serves as a forum for linking various underlying components in broad and interdisciplinary means, while maintaining balance between applied and fundamental research. Topics we are interested in receiving reviews on are the following: · chemical analysis; · instrumentation; · chemometrics; · analytical biochemistry; · medicinal analysis; · forensics; · environmental sciences; · applied physics; · and material science.
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