Subretinal drusenoid deposits, age-related macular degeneration, and cardiovascular disease

IF 3.7 3区医学 Q1 OPHTHALMOLOGY

Asia-Pacific Journal of Ophthalmology Pub Date : 2024-01-01 DOI:10.1016/j.apjo.2024.100036

R. Theodore Smith , Timothy W. Olsen , Victor Chong , Judy Kim , Martin Hammer , Gareth Lema , Avnish Deobhakta , Anna Tan , Yuehong Tong , Katy Tai , Yang Fei , Emanuel Mordechaev , Gerardo Ledesma-Gil , Oscar Otero-Marquez , Richard B Rosen , Alauddin Bhuiyan , Sobha Sivaprasad , Philip J. Rosenfeld

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引用次数: 0

Abstract

Decades of studies on age-related macular degeneration (AMD), cardiovascular disease and stroke have not found consistent associations between AMD and systemic vascular disease. This study suggests that there is in fact no general relationship, but instead a strong, specific association between only the subretinal drusenoid deposit (SDD) phenotype of AMD on retinal imaging and certain co-existent vascular diseases that are high risk for compromised cardiac output or internal carotid artery stenosis. Future screening initiatives for these high -risk vascular diseases (HRVDs) with fast, inexpensive retinal imaging could make a significant contribution to public health and save lives. Likewise, screening patients with known HRVDs for unrecognized AMD of the SDD form could enable needed treatment and save vision.

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视网膜下类风湿因子沉积、老年黄斑变性和心血管疾病。

数十年来，有关老年性黄斑变性（AMD）、心血管疾病和中风的研究并未发现 AMD 与全身血管疾病之间存在一致的关联。这项研究表明，事实上两者之间并不存在普遍关系，相反，只有视网膜成像上的视网膜下类风湿沉积物（SDD）表型与某些并存的血管疾病之间存在强烈的特殊关联，而这些血管疾病是心输出量受损或颈内动脉狭窄的高危因素。未来利用快速、廉价的视网膜成像技术筛查这些高危血管疾病（HRVDs）的举措将为公共卫生和挽救生命做出重大贡献。同样，对已知患有高危血管疾病但未被发现的 SDD 型老年性视网膜病变患者进行筛查，也能提供必要的治疗并挽救视力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asia-Pacific Journal of Ophthalmology OPHTHALMOLOGY-

CiteScore

8.10

自引率

18.20%

发文量

197

审稿时长

6 weeks

期刊介绍： The Asia-Pacific Journal of Ophthalmology, a bimonthly, peer-reviewed online scientific publication, is an official publication of the Asia-Pacific Academy of Ophthalmology (APAO), a supranational organization which is committed to research, training, learning, publication and knowledge and skill transfers in ophthalmology and visual sciences. The Asia-Pacific Journal of Ophthalmology welcomes review articles on currently hot topics, original, previously unpublished manuscripts describing clinical investigations, clinical observations and clinically relevant laboratory investigations, as well as .perspectives containing personal viewpoints on topics with broad interests. Editorials are published by invitation only. Case reports are generally not considered. The Asia-Pacific Journal of Ophthalmology covers 16 subspecialties and is freely circulated among individual members of the APAO’s member societies, which amounts to a potential readership of over 50,000.