Left Atrial Glucose Metabolism Evaluation by 18F-FDG-PET in Persistent Atrial Fibrillation and in Sinus Rhythm

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC: Basic to Translational Science Pub Date : 2024-04-01 DOI:10.1016/j.jacbts.2023.11.001

Sébastien Marchandise MD , Véronique Roelants MD, PhD , Tristan Raoult MD , Quentin Garnir MD , Christophe Scavée MD , Varnavas Varnavas MD PhD , Aurélien Wauters MD, PhD , Damien Gruson MD, PhD , Eric Nellessen MD , Michel Hesse PhD , Christophe Beauloye MD, PhD , Bernhard L. Gerber MD, PhD

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Abstract

The role of atrial metabolism alterations for initiation and atrial fibrillation (AF) persistence remains poorly understood. Therefore, we evaluated left atrial glucose metabolism by nicotinic acid derivative stimulated 18-fluorodeoxyglucose positron emission tomography in 36 patients with persistent AF undergoing catheter ablation before and 3 months after return to sinus rhythm and compared values against healthy controls. Under identical hemodynamics and metabolic conditions, and although left ventricular FDG uptake remained unchanged, patients in persistent AF presented significantly higher total left atrial and left atrial appendage uptake, which decreased significantly after return to sinus rhythm, despite improvement of passive and active atrial contractile function. These findings support a role of altered glucose metabolism and metabolic wasting underlying the pathophysiology of persistent AF.

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通过 18F-FDG-PET 评估持续性心房颤动和窦性心律的左心房葡萄糖代谢情况

人们对心房代谢改变在心房颤动（房颤）起始和持续中的作用仍知之甚少。因此，我们通过烟酸衍生物刺激 18 氟脱氧葡萄糖正电子发射断层扫描评估了 36 名接受导管消融术的持续性房颤患者在恢复窦性心律前和恢复窦性心律后 3 个月的左心房葡萄糖代谢情况，并将其值与健康对照组进行了比较。在相同的血液动力学和新陈代谢条件下，虽然左心室 FDG 摄取量保持不变，但持续性房颤患者的左心房和左心房附壁总摄取量明显较高，尽管被动和主动心房收缩功能有所改善，但恢复窦性心律后摄取量明显下降。这些研究结果支持葡萄糖代谢改变和代谢消耗在持续性房颤病理生理学中的作用。

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来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.