Photoacoustic viscoelasticity assessment of prefrontal cortex and cerebellum in normal and prenatal valproic acid-exposed rats

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics Pub Date : 2024-01-20 DOI:10.1016/j.pacs.2024.100590

Zahra Hosseindokht , Shima Davoudi , Mona Rahdar , Mahyar Janahmadi , Mohammadreza Kolahdouz , Pezhman Sasanpoour

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Abstract

Mechanical properties of brain tissues are from principal features from different points of view; diagnosis, the performance of the brain and neurological disorders. Particularly viscoelastic properties of the brain tissues are determinative. In this study based on a proposed accurate and non-invasive method, we have measured the viscoelastic properties of prefrontal cortex and cerebellum, two important brain regions involved in motor learning and pathophysiology of autism spectrum disorder (ASD). In this regard, using photoacoustic systems, viscoelastic properties of tissues from the cerebellum and prefrontal cortex of normal and prenatal VPA (Valproic acid)-exposed (i.e. autistic-like) offspring rats are measured. Results of our study show that the cerebellums of normal tissues are stiffer than the tissue obtained from autistic-like rats, while the viscoelasticity of the prefrontal cortex of normal tissues is higher than that of autistic ones. The proposed method for the measurement of viscoelastic properties of the brain tissue has the potential not only for the fundamental studies but as a diagnosis technique.

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正常大鼠和产前丙戊酸暴露大鼠前额叶皮层和小脑的光声粘弹性评估

从诊断、大脑功能和神经系统疾病等不同角度来看，脑组织的机械特性是其主要特征。尤其是脑组织的粘弹性能具有决定性作用。在这项研究中，我们基于一种拟议的精确无创方法，测量了前额叶皮层和小脑的粘弹性能，这两个重要的脑区参与了自闭症谱系障碍（ASD）的运动学习和病理生理学。为此，我们使用光声系统测量了正常大鼠和产前接触过 VPA（丙戊酸）（即类似自闭症）的后代大鼠的小脑和前额叶皮层组织的粘弹性。研究结果表明，正常组织的小脑比自闭症样大鼠的小脑硬，而正常组织的前额叶皮层的粘弹性比自闭症样大鼠的前额叶皮层的粘弹性高。所提出的测量脑组织粘弹性的方法不仅可用于基础研究，还可作为一种诊断技术。

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.