Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: A conceptual model for the study of sex and gender differences

IF 6.5 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Frontiers in Neuroendocrinology Pub Date : 2024-01-20 DOI:10.1016/j.yfrne.2024.101121

Alexandra Donovan , Shervin Assari , Christine Grella , Magda Shaheen , Linda Richter , Theodore C. Friedman

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引用次数: 0

Abstract

Early life stress (ELS) is defined as an acute or chronic stressor that negatively impacts a child’s development. ELS is associated with substance use and mental health problems. This narrative literature review focuses on sex and gender differences in the effects of ELS on 1) adolescent neuroendocrine development; 2) pubertal brain maturation; and 3) development of internalizing symptoms and subsequent substance use. We posit that ELS may generate larger hormonal dysregulation in females than males during puberty, increasing internalizing symptoms and substance use. Future research should consider sex and gender differences in neuroendocrine developmental processes when studying the link between ELS and negative health outcomes.

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早期生活压力、情感和青少年药物使用之间联系的神经内分泌机制：研究性和性别差异的概念模型

早期生活压力（ELS）是指对儿童成长产生负面影响的急性或慢性压力。ELS 与药物使用和心理健康问题有关。这篇叙述性文献综述的重点是 ELS 对以下方面影响的性别差异：1）青少年神经内分泌发育；2）青春期大脑成熟；3）内化症状的发展及随后的药物使用。我们认为，在青春期，ELS 可能会对女性产生比男性更大的荷尔蒙失调，从而增加内化症状和药物使用。在研究 ELS 与负面健康结果之间的联系时，未来的研究应考虑神经内分泌发育过程中的性别差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neuroendocrinology 医学-内分泌学与代谢

CiteScore

13.30

自引率

6.80%

发文量

审稿时长

68 days

期刊介绍： Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.