Effects of music on cognitive behavioral impairments in both sex of adult rats exposed prenatally to valproic acid

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2024-01-19 DOI:10.1002/bdr2.2300

Farahnaz Taheri, Sara Joushi, Lily Mohammadipoor-Ghasemabad, Iman Rad, Khadijeh Esmaeilpour, Vahid Sheibani

{"title":"Effects of music on cognitive behavioral impairments in both sex of adult rats exposed prenatally to valproic acid","authors":"Farahnaz Taheri, Sara Joushi, Lily Mohammadipoor-Ghasemabad, Iman Rad, Khadijeh Esmaeilpour, Vahid Sheibani","doi":"10.1002/bdr2.2300","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in reciprocal social interactions, deficits in communication, and restrictive and repetitive behaviors and interests. In previous studies, music has been identified as an intervention therapy for children with ASD.</p>\n </section>\n \n <section>\n \n <h3> Objectives</h3>\n \n <p>The present study evaluated the effects of music on cognitive behavioral impairments in both sexes of adult rats exposed prenatally to Valproic acid.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>For induction of autism, pregnant female rats were pretreated with either saline or VPA (600 mg/kg.i.p.) at gestational day (GD) 12.5. Male and female offspring were divided into Saline.Non-Music, VPA.Non-Music, Saline.Music, and VPA.Music groups. The adult rats in the music groups were exposed to Mozart's piano sonata K.448 for 30 days (4 h/day), from postnatal day (PND) 60 to 90. Social interaction and Morris water maze (MWM) tasks were tested at PND 90.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Our results revealed that prenatal exposure to VPA decreased sociability and social memory performance in both sexes of adult rats. Moreover, prenatal exposure to VPA created learning and memory impairments in both sexes of adult rats in the MWM task. Music intervention improved sociability in both sexes of VPA-exposed rats and social memory in both sexes of VPA-exposed rats, especially in females. Furthermore, our results revealed that music ameliorated learning impairments in VPA-exposed female rats in the MWM task. In addition, music improved spatial memory impairments in VPA-exposed rats of both sexes, especially in females, which needs more investigation in molecular and histological fields in future studies.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Music intervention improved sociability and social memory in adult VPA-exposed rats, especially in female animals. Furthermore, music improved memory impairments in VPA-exposed rats of both sexes. It seems that music had a better influence on female rats. However, future studies need more investigations in molecular and histological fields.</p>\n </section>\n </div>","PeriodicalId":9121,"journal":{"name":"Birth Defects Research","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Birth Defects Research","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2300","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in reciprocal social interactions, deficits in communication, and restrictive and repetitive behaviors and interests. In previous studies, music has been identified as an intervention therapy for children with ASD.

Objectives

The present study evaluated the effects of music on cognitive behavioral impairments in both sexes of adult rats exposed prenatally to Valproic acid.

Methods

For induction of autism, pregnant female rats were pretreated with either saline or VPA (600 mg/kg.i.p.) at gestational day (GD) 12.5. Male and female offspring were divided into Saline.Non-Music, VPA.Non-Music, Saline.Music, and VPA.Music groups. The adult rats in the music groups were exposed to Mozart's piano sonata K.448 for 30 days (4 h/day), from postnatal day (PND) 60 to 90. Social interaction and Morris water maze (MWM) tasks were tested at PND 90.

Results

Our results revealed that prenatal exposure to VPA decreased sociability and social memory performance in both sexes of adult rats. Moreover, prenatal exposure to VPA created learning and memory impairments in both sexes of adult rats in the MWM task. Music intervention improved sociability in both sexes of VPA-exposed rats and social memory in both sexes of VPA-exposed rats, especially in females. Furthermore, our results revealed that music ameliorated learning impairments in VPA-exposed female rats in the MWM task. In addition, music improved spatial memory impairments in VPA-exposed rats of both sexes, especially in females, which needs more investigation in molecular and histological fields in future studies.

Conclusion

Music intervention improved sociability and social memory in adult VPA-exposed rats, especially in female animals. Furthermore, music improved memory impairments in VPA-exposed rats of both sexes. It seems that music had a better influence on female rats. However, future studies need more investigations in molecular and histological fields.

查看原文本刊更多论文

音乐对产前暴露于丙戊酸的成年雌雄大鼠认知行为障碍的影响

背景自闭症谱系障碍（ASD）是一种神经发育障碍，其特征是互惠的社会交往障碍、沟通障碍以及限制性和重复性的行为和兴趣。在以往的研究中，音乐被认为是一种针对 ASD 儿童的干预疗法。本研究评估了音乐对产前暴露于丙戊酸的成年雌雄大鼠认知行为障碍的影响。方法为了诱导自闭症，怀孕雌性大鼠在妊娠日（GD）12.5时接受生理盐水或VPA（600 mg/kg.i.p.）预处理。雄性和雌性后代被分为生理盐水非音乐组、VPA非音乐组、生理盐水音乐组和VPA音乐组。音乐组的成年大鼠在出生后第 60 至 90 天接触莫扎特钢琴奏鸣曲 K.448，为期 30 天（每天 4 小时）。在出生后第 90 天进行了社交互动和莫里斯水迷宫（MWM）任务测试。结果我们的研究结果表明，产前暴露于 VPA 会降低成年大鼠的社交能力和社会记忆能力。此外，产前暴露于VPA会导致成年大鼠在MWM任务中出现学习和记忆障碍。音乐干预改善了暴露于VPA的雌雄大鼠的社交能力，也改善了暴露于VPA的雌雄大鼠的社会记忆，尤其是雌性大鼠。此外，我们的研究结果表明，音乐能改善暴露于 VPA 的雌性大鼠在 MWM 任务中的学习障碍。此外，音乐还改善了暴露于 VPA 的雌雄大鼠的空间记忆障碍，尤其是雌性大鼠，这需要在今后的研究中从分子和组织学领域进行更多的调查。结论音乐干预改善了暴露于 VPA 的成年大鼠的社交能力和社交记忆，尤其是雌性大鼠。此外，音乐还改善了暴露于 VPA 的雌雄大鼠的记忆障碍。似乎音乐对雌性大鼠的影响更大。不过，未来的研究还需要在分子和组织学领域进行更多的调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.

文献相关原料

公司名称	产品信息	采购帮参考价格