sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence.

IF 5.2 2区医学 Q1 GERIATRICS & GERONTOLOGY

Immunity & Ageing Pub Date : 2024-01-20 DOI:10.1186/s12979-023-00405-0

Andrea Aprilia, Kusworini Handono, Hidayat Sujuti, Akhmad Sabarudin, Nuning Winaris

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引用次数: 0

Abstract

Background: Inflammaging, the characteristics of immunosenescence, characterized by continuous chronic inflammation that could not be resolved. It is not only affect older people but can also occur in young individuals, especially those suffering from chronic inflammatory conditions such as autoimmune disease, malignancy, or chronic infection. This condition led to altered immune function and as consequent immune function is reduced. Detection of immunosenescence has been done by examining the immune risk profile (IRP), which uses flow cytometry. These tests are not always available in health facilities, especially in developing countries and require fresh whole blood samples. Therefore, it is necessary to find biomarkers that can be tested using stored serum to make it easier to refer to the examination. Here we proposed an insight for soluble biomarkers which represented immune cells activities and exhaustion, namely sCD163, sCD28, sCD80, and sCTLA-4. Those markers were reported to be elevated in chronic diseases that caused early aging and easily detected from serum samples using ELISA method, unlike IRP. Therefore, we conclude these soluble markers are beneficial to predict pathological condition of immunosenescence.

Aim: To identify soluble biomarkers that could replace IRP for detecting immunosenescence.

Conclusion: Soluble costimulatory molecule suchsCD163, sCD28, sCD80, and sCTLA-4 are potential biomarkers for detecting immunosenescence.

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sCD163、sCD28、sCD80 和 sCTLA-4 作为检测免疫衰老的可溶性候选标记物。

背景：炎症是免疫衰老的特征，其特点是持续的慢性炎症无法消除。它不仅影响老年人，也可能发生在年轻人身上，尤其是那些患有慢性炎症的人，如自身免疫性疾病、恶性肿瘤或慢性感染。这种情况导致免疫功能改变，免疫功能随之降低。检测免疫衰老的方法是使用流式细胞仪检测免疫风险谱（IRP）。这些检测并不总能在医疗机构中进行，尤其是在发展中国家，而且需要新鲜的全血样本。因此，有必要找到可使用储存血清进行检测的生物标志物，以便于参考检查。在此，我们提出了一种代表免疫细胞活性和衰竭的可溶性生物标志物，即 sCD163、sCD28、sCD80 和 sCTLA-4。据报道，这些标志物在导致早衰的慢性疾病中会升高，而且与 IRP 不同，它们很容易用 ELISA 方法从血清样本中检测出来。因此，我们认为这些可溶性标记物有利于预测免疫衰老的病理状况：结论：CD163、sCD28、sCD80 和 sCTLA-4 等可溶性成本调节分子是检测免疫衰老的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY

CiteScore

10.20

自引率

3.80%

发文量

期刊介绍： Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.