Using the Right Criteria for MCAS.

IF 5.4 2区医学 Q1 ALLERGY

Current Allergy and Asthma Reports Pub Date : 2024-02-01 Epub Date: 2024-01-20 DOI:10.1007/s11882-024-01126-0

Theo Gulen

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引用次数: 0

Abstract

Purpose of review: The current article aims to provide a comprehensive update on diagnostic criteria for mast cell activation syndrome (MCAS), addressing challenges in diagnosing and classifying MCAS and its variants.

Recent findings: In recent years, there has been a significant increase in our knowledge regarding the underlying mechanisms responsible for the activation of mast cells (MCs) in various pathological conditions. Furthermore, a set of criteria and a classification for MCASs have been established. MCAS is characterized by the presence of typical clinical symptoms, a substantial elevation in serum tryptase levels during an attack compared to the patient's baseline tryptase levels, and a response to MC mediator-targeting therapy. In this report, a thorough examination was conducted on the contemporary literature relating to MCAS, with a focus on comparing the specificity, sensitivity, and robustness of MCAS-related parameters within proposals for diagnosing and classifying MCAS and its variants. Moreover, the significance of employing specific consensus criteria in the assessment and categorization of MCAS in individual patients was underscored, due to the escalating occurrence of patients receiving a misdiagnosis of MCAS based on nonspecific criteria.

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为 MCAS 使用正确的标准。

综述的目的：本文旨在全面更新肥大细胞活化综合征（MCAS）的诊断标准，解决肥大细胞活化综合征及其变异体的诊断和分类难题：近年来，我们对各种病理情况下肥大细胞（MCs）活化的基本机制有了更多的了解。此外，我们还建立了一套肥大细胞综合征的标准和分类方法。肥大细胞活化症的特征是存在典型的临床症状，发作时血清胰蛋白酶水平与患者的基线胰蛋白酶水平相比大幅升高，以及对肥大细胞介质靶向治疗有反应。本报告对有关 MCAS 的当代文献进行了深入研究，重点是比较 MCAS 相关参数在诊断和分类 MCAS 及其变异型的建议中的特异性、敏感性和稳健性。此外，由于根据非特异性标准误诊为 MCAS 的患者越来越多，因此强调了在评估和分类 MCAS 时采用特异性共识标准的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Allergy and Asthma Reports 医学-过敏

CiteScore

11.20

自引率

1.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of Current Allergy and Asthma Reports is to systematically provide the views of highly selected experts on current advances in the fields of allergy and asthma and highlight the most important papers recently published. All reviews are intended to facilitate the understanding of new advances in science for better diagnosis, treatment, and prevention of allergy and asthma. We accomplish this aim by appointing international experts in major subject areas across the discipline to review select topics emphasizing recent developments and highlighting important new papers and emerging concepts. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. Over a one- to two-year period, readers are updated on all the major advances in allergy and asthma.