KOH-catalyzed cross-coupling of primary and secondary alcohols: evidence for radical pathways

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemical Sciences Pub Date : 2024-01-18 DOI:10.1007/s12039-023-02241-7

Amlan Subhadarshi Nayak, Shubham Jaiswal, Manas Kumar Sahu, Chidambaram Gunanathan

引用次数: 0

Abstract

A simple base, KOH-catalyzed cross-coupling of primary and secondary alcohols is reported in which the primary alcohols play the role of alkylation reagents. EPR and mechanistic studies confirmed the involvement of radical and ketone intermediates formed from primary and secondary alcohols, respectively, leading to the formation of β-alkylated secondary alcohols.

Graphical abstract

A simple base-catalyzed synthesis of higher secondary alcohols directly from the cross-coupling of primary and secondary alcohols is reported.

Abstract Image

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KOH 催化的伯醇和仲醇交叉偶联：自由基途径的证据

报告了一种简单的碱、KOH 催化的伯醇和仲醇交叉偶联反应，其中伯醇起着烷基化试剂的作用。EPR 和机理研究证实了由伯醇和仲醇分别形成的自由基和酮中间体的参与，导致了 β-烷基化仲醇的形成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Chemical Sciences CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.10

自引率

5.90%

发文量

107

审稿时长

1 months

期刊介绍： Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.