{"title":"Difluorocarbene-enabled synthesis of 18F-radiotracers in positron emission tomography","authors":"Xiaohui Liu , Chunyang Huan , Xiaofeng Zhang , Wei Zhang","doi":"10.1016/j.jfluchem.2024.110253","DOIUrl":null,"url":null,"abstract":"<div><p>Positron emission tomography (PET) is a preclinical and clinical imaging technique that is extensively used in biomedical research and disease diagnosis to study and visualize biological and physiological processes. The positron emitter used most frequently for PET imaging is fluorine-18 (<sup>18</sup>F) due to its practical 109.8 min half-life, high yield production on fragile biomedical cyclotrons, and well-established <sup>18</sup>F-radiochemistry. Fluorine atom(s) presented in many drugs and biomarkers that provides the opportunity for the development radioligand-labeled with <sup>18</sup>F. Summarized in this paper are difluorocarbene (DFC)-enabled <sup>18</sup>F-radiosynthesis to introduce [<sup>18</sup>F]CF<sub>3</sub>, [<sup>18</sup>F]CF<sub>2</sub> and related motifs in organic molecules and to use them as bioactive radiotracers.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022113924000149","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Positron emission tomography (PET) is a preclinical and clinical imaging technique that is extensively used in biomedical research and disease diagnosis to study and visualize biological and physiological processes. The positron emitter used most frequently for PET imaging is fluorine-18 (18F) due to its practical 109.8 min half-life, high yield production on fragile biomedical cyclotrons, and well-established 18F-radiochemistry. Fluorine atom(s) presented in many drugs and biomarkers that provides the opportunity for the development radioligand-labeled with 18F. Summarized in this paper are difluorocarbene (DFC)-enabled 18F-radiosynthesis to introduce [18F]CF3, [18F]CF2 and related motifs in organic molecules and to use them as bioactive radiotracers.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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