Self-Immolative Electrochemical Redox Substrates: Emerging Artificial Receptors in Sensing and Biosensing

IF 4.6 Q1 CHEMISTRY, ANALYTICAL
Kesavan Manibalan, Ponnusamy Arul, Hsin-Jay Wu, Sheng-Tung Huang* and Veerappan Mani*, 
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Abstract

The development of artificial receptors has great significance in measurement science and technology. The need for a robust version of natural receptors is getting increased attention because the cost of natural receptors is still high along with storage difficulties. Aptamers, imprinted polymers, and nanozymes are some of the matured artificial receptors in analytical chemistry. Recently, a new direction has been discovered by organic chemists, who can synthesize robust, activity-based, self-immolative organic molecules that have artificial receptor properties for the targeted analytes. Specifically designed trigger moieties implant selectivity and sensitivity. These latent electrochemical redox substrates are highly stable, mass-producible, inexpensive, and eco-friendly. Combining redox substrates with the merits of electrochemical techniques is a good opportunity to establish a new direction in artificial receptors. This Review provides an overview of electrochemical redox substrate design, anatomy, benefits, and biosensing potential. A proper understanding of molecular design can lead to the development of a library of novel self-immolative redox molecules that would have huge implications for measurement science and technology.

Abstract Image

Abstract Image

自惰性电化学氧化还原底物:传感和生物传感领域的新兴人工受体
人工受体的开发在测量科学和技术领域具有重要意义。由于天然受体的成本仍然很高,而且难以储存,因此对天然受体的稳健版本的需求日益受到关注。在分析化学领域,一些成熟的人工受体包括肽聚体、印迹聚合物和纳米酶。最近,有机化学家发现了一个新的方向,他们可以合成稳健的、基于活性的、具有目标分析物人工受体特性的自惰性有机分子。专门设计的触发分子可植入选择性和灵敏度。这些潜在的电化学氧化还原底物高度稳定、可大规模生产、价格低廉且环保。将氧化还原底物与电化学技术的优点相结合,是开创人工受体新方向的良机。本综述概述了电化学氧化还原底物的设计、解剖、优点和生物传感潜力。正确理解分子设计可以开发出新型自惰性氧化还原分子库,这将对测量科学和技术产生巨大影响。
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来源期刊
ACS Measurement Science Au
ACS Measurement Science Au 化学计量学-
CiteScore
5.20
自引率
0.00%
发文量
0
期刊介绍: ACS Measurement Science Au is an open access journal that publishes experimental computational or theoretical research in all areas of chemical measurement science. Short letters comprehensive articles reviews and perspectives are welcome on topics that report on any phase of analytical operations including sampling measurement and data analysis. This includes:Chemical Reactions and SelectivityChemometrics and Data ProcessingElectrochemistryElemental and Molecular CharacterizationImagingInstrumentationMass SpectrometryMicroscale and Nanoscale systemsOmics (Genomics Proteomics Metabonomics Metabolomics and Bioinformatics)Sensors and Sensing (Biosensors Chemical Sensors Gas Sensors Intracellular Sensors Single-Molecule Sensors Cell Chips Arrays Microfluidic Devices)SeparationsSpectroscopySurface analysisPapers dealing with established methods need to offer a significantly improved original application of the method.
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