Dose-response effects of exercise on mental health in community-dwelling older adults: Exploration of genetic moderators

IF 5.3 1区心理学 Q1 PSYCHOLOGY, CLINICAL

International Journal of Clinical and Health Psychology Pub Date : 2024-01-01 DOI:10.1016/j.ijchp.2024.100443

Swathi Gujral , Marcia Burns , Kirk I Erickson , Dana Rofey , Jeremiah J Peiffer , Simon M. Laws , Belinda Brown

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引用次数: 0

Abstract

Background/Objective

(1) Examine the role of exercise intensity on mental health symptoms in a community-based sample of older adults. (2) Explore the moderating role of genetic variation in brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) on the effects of exercise on mental health symptoms.

Method

This study is a secondary analysis of a three-arm randomized controlled trial, comparing the effects of 6 months of high-intensity aerobic training vs. moderate-intensity aerobic training vs. a no-contact control group on mental health symptoms assessed using the Depression, Anxiety, and Stress Scale (DASS). The BDNF Val66Met polymorphism and APOE ε4 carrier status were explored as genetic moderators of exercise effects on mental health symptoms.

Results

The exercise intervention did not influence mental health symptoms. The BDNF Val66Met polymorphism did not moderate intervention effects on mental health symptoms. APOE ε4 carrier status moderated the effect of intervention group on perceived stress over 6 months, such that APOE ε4 carriers, but not non-carriers, in the high-intensity aerobic training group showed a decline in perceived stress over 6 months.

Conclusions

APOE ε4 carrier status may modify the benefits of high-intensity exercise on perceived stress such that APOE ε4 carriers show a greater decline in stress as a result of exercise relative to non-APOE ε4 carriers.

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运动对社区老年人心理健康的剂量-反应效应：基因调节因素探究

背景/目的（1）在社区老年人样本中研究运动强度对心理健康症状的影响。(2）探讨脑源性神经营养因子（BDNF）和载脂蛋白 E（APOE）的遗传变异对运动对精神健康症状影响的调节作用。本研究是一项三臂随机对照试验的二次分析，比较了 6 个月高强度有氧训练与中等强度有氧训练以及无接触对照组对使用抑郁、焦虑和压力量表（DASS）评估的精神健康症状的影响。研究还探讨了BDNF Val66Met多态性和APOE ε4携带者状态对运动影响心理健康症状的遗传调节作用。BDNF Val66Met多态性没有调节干预对心理健康症状的影响。APOE ε4携带者的身份调节了干预组对6个月内感知压力的影响，因此高强度有氧训练组的APOE ε4携带者（而非非携带者）在6个月内感知压力有所下降。

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来源期刊

International Journal of Clinical and Health Psychology PSYCHOLOGY, CLINICAL-

CiteScore

10.70

自引率

5.70%

发文量

审稿时长

33 days

期刊介绍： The International Journal of Clinical and Health Psychology is dedicated to publishing manuscripts with a strong emphasis on both basic and applied research, encompassing experimental, clinical, and theoretical contributions that advance the fields of Clinical and Health Psychology. With a focus on four core domains—clinical psychology and psychotherapy, psychopathology, health psychology, and clinical neurosciences—the IJCHP seeks to provide a comprehensive platform for scholarly discourse and innovation. The journal accepts Original Articles (empirical studies) and Review Articles. Manuscripts submitted to IJCHP should be original and not previously published or under consideration elsewhere. All signing authors must unanimously agree on the submitted version of the manuscript. By submitting their work, authors agree to transfer their copyrights to the Journal for the duration of the editorial process.