Prognostic Nutritional Index after Introduction of Atezolizumab with Bevacizumab Predicts Prognosis in Advanced Hepatocellular Carcinoma: A Multicenter Study.

IF 2.5 3区医学 Q3 ONCOLOGY

Oncology Pub Date : 2024-01-01 Epub Date: 2024-01-18 DOI:10.1159/000536367

Takanori Suzuki, Kentaro Matsuura, Yuta Suzuki, Fumihiro Okumura, Yoshihito Nagura, Satoshi Sobue, Daisuke Kato, Atsunori Kusakabe, Hiroki Koguchi, Izumi Hasegawa, Sho Matoya, Tomokatsu Miyaki, Yoshihide Kimura, Yoshito Tanaka, Hiromu Kondo, Atsushi Ozasa, Hayato Kawamura, Kayoko Kuno, Kei Fujiwara, Shunsuke Nojiri, Hiromi Kataoka

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引用次数: 0

Abstract

Introduction: Atezolizumab plus bevacizumab (Atez/Bev) is the preferred treatment for advanced hepatocellular carcinoma (HCC). However, biomarkers of therapeutic efficacy have remained unclear. We took a retrospective approach to explore the role of prognostic nutritional index (PNI) for predicting the outcomes of Atez/Bev treatment.

Methods: One hundred 25 HCC patients were enlisted; these patients received Atez/Bev treatment and underwent dynamic computerized tomography/magnetic resonance imaging to determine the treatment response on at least one occasion between October 2020 and January 2023, and their PNI before treatment and at the beginning of the second cycle (PNI-2c) was evaluated.

Results: During the initial evaluation, 2 (2%), 28 (22%), 70 (56%), and 25 (20%) patients exhibited a complete response, partial response, stable disease, and progressive disease (PD), respectively. Patients with non-PD tended to have higher PNI at baseline and PNI-2c than those with PD (p = 0.245 and 0.122, respectively), with optimal baseline PNI and PNI-2c cut-off values of 42.6 and 40.4, respectively. PNI at baseline could not be used to predict overall survival (OS) or progression-free survival (PFS). However, PNI-2c predicted OS and PFS (PNI-2c ≥ 40.4 vs. < 40.4: 25.3 vs. 16.2 months, p = 0.008 for OS; 12.7 vs. 8.4 months, p = 0.036 for PFS). A multivariate analysis showed a significant association between PNI-2c and OS.

Conclusions: PNI-2c is a predictor of prognosis in HCC patients treated with Atez/Bev therapy.

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采用阿特珠单抗和贝伐单抗后的预后营养指数可预测晚期肝细胞癌的预后：一项多中心研究。

简介阿特珠单抗加贝伐单抗（Atez/Bev）是治疗晚期肝细胞癌（HCC）的首选疗法。然而，疗效的生物标志物仍不明确。我们采用回顾性方法探讨了预后营养指数（PNI）在预测Atez/Bev治疗效果方面的作用：这些患者接受了Atez/Bev治疗，并在2020年10月至2023年1月期间至少一次接受了动态计算机断层扫描/磁共振成像以确定治疗反应，同时评估了他们治疗前和第二周期开始时的PNI（PNI-2c）：在初次评估中，分别有2例（2%）、28例（22%）、70例（56%）和25例（20%）患者表现出完全应答（CR）、部分应答（PR）、疾病稳定（SD）和疾病进展（PD）。非进展期患者的基线 PNI 和 PNI-2c 往往高于进展期患者（P = 0.245 和 0.122），最佳基线 PNI 和 PNI-2c 临界值分别为 42.6 和 40.4。基线 PNI 不能用于预测总生存期（OS）或无进展生存期（PFS）。然而，PNI-2c 可预测 OS 和 PFS（PNI-2c ≥ 40.4 vs. < 40.4：OS 为 25.3 vs. 16.2 个月，P = 0.008；PFS 为 12.7 vs. 8.4 个月，P = 0.036）。多变量分析显示，PNI-2c与OS之间存在显著关联：结论：PNI-2c可预测接受Atez/Bev治疗的HCC患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncology 医学-肿瘤学

CiteScore

6.00

自引率

2.90%

发文量

审稿时长

6-12 weeks

期刊介绍： Although laboratory and clinical cancer research need to be closely linked, observations at the basic level often remain removed from medical applications. This journal works to accelerate the translation of experimental results into the clinic, and back again into the laboratory for further investigation. The fundamental purpose of this effort is to advance clinically-relevant knowledge of cancer, and improve the outcome of prevention, diagnosis and treatment of malignant disease. The journal publishes significant clinical studies from cancer programs around the world, along with important translational laboratory findings, mini-reviews (invited and submitted) and in-depth discussions of evolving and controversial topics in the oncology arena. A unique feature of the journal is a new section which focuses on rapid peer-review and subsequent publication of short reports of phase 1 and phase 2 clinical cancer trials, with a goal of insuring that high-quality clinical cancer research quickly enters the public domain, regardless of the trial’s ultimate conclusions regarding efficacy or toxicity.