Altered lipid metabolism as a predisposing factor for liver metastasis in MASLD

IF 3.7 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules and Cells Pub Date : 2024-02-01 DOI:10.1016/j.mocell.2024.100010

So Jung Kim , Jeongeun Hyun

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引用次数: 0

Abstract

Recently, the incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing due to the high prevalence of metabolic conditions, such as obesity and type 2 diabetes mellitus. Steatotic liver is a hotspot for cancer metastasis in MASLD. Altered lipid metabolism, a hallmark of MASLD, remodels the tissue microenvironment, making it conducive to the growth of metastatic liver cancer. Tumors exacerbate the dysregulation of hepatic metabolism by releasing extracellular vesicles and particles into the liver. Altered lipid metabolism influences the proliferation, differentiation, and functions of immune cells, contributing to the formation of an immunosuppressive and metastasis-prone liver microenvironment in MASLD. This review discusses the mechanisms by which the steatotic liver promotes liver metastasis progression, focusing on its role in fostering an immunosuppressive microenvironment in MASLD. Furthermore, this review highlights lipid metabolism manipulation strategies for the therapeutic management of metastatic liver cancer.

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脂质代谢改变是MASLD肝转移的诱发因素。

最近，由于肥胖和 2 型糖尿病等代谢性疾病的高发病率，代谢功能障碍相关性脂肪性肝病（MASLD）的发病率正在上升。脂肪肝是 MASLD 中癌症转移的热点。脂质代谢改变是MASLD的特征之一，它重塑了组织微环境，使其有利于转移性肝癌的生长。肿瘤通过向肝脏释放细胞外囊泡和颗粒，加剧肝脏代谢失调。脂质代谢的改变会影响免疫细胞的增殖、分化和功能，从而在 MASLD 中形成免疫抑制和易转移的肝脏微环境。本综述讨论了脂肪肝促进肝转移进展的机制，重点关注脂肪肝在MASLD中形成免疫抑制微环境的作用。此外，本综述还强调了转移性肝癌治疗中的脂质代谢控制策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecules and Cells 生物-生化与分子生物学

CiteScore

6.60

自引率

10.50%

发文量

审稿时长

2.3 months

期刊介绍： Molecules and Cells is an international on-line open-access journal devoted to the advancement and dissemination of fundamental knowledge in molecular and cellular biology. It was launched in 1990 and ISO abbreviation is ''Mol. Cells''. Reports on a broad range of topics of general interest to molecular and cell biologists are published. It is published on the last day of each month by the Korean Society for Molecular and Cellular Biology.