Resveratrol improves diabetic kidney disease by modulating the gut microbiota-short chain fatty acids axis in db/db mice.

IF 3.5 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY
Hongjia Yan, Yi Zhang, Xiaoqian Lin, Juan Huang, Fuwei Zhang, Caiyu Chen, Hongmei Ren, Shuo Zheng, Jian Yang, Suocheng Hui
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Abstract

Diabetic kidney disease is associated with the dysbiosis of the gut microbiota and its metabolites. db/db mice were fed chow diet with or without 0.4% resveratrol for 12 weeks, after which the gut microbiota, faecal short-chain fatty acids (SCFAs), and renal fibrosis were analysed. Resveratrol ameliorated the progression of diabetic kidney disease and alleviated tubulointerstitial fibrosis. Further studies showed that gut microbiota dysbiosis was modulated by resveratrol, characterised by the expansion of SCFAs-producing bacteria Faecalibaculum and Lactobacillus, which increased the concentrations of SCFAs (especially acetic acid) in the faeces. Moreover, microbiota transplantation experiments found that alteration of the gut microbiota contributed to the prevention of diabetic kidney disease. Acetate treatment ameliorated proteinuria, glomerulosclerosis and tubulointerstitial fibrosis in db/db mice. Overall, resveratrol improved the progression of diabetic kidney disease by suppressing tubulointerstitial fibrosis, which may be involved, at least in part, in the regulation of the gut microbiota-SCFAs axis.

白藜芦醇通过调节 db/db 小鼠肠道微生物群-短链脂肪酸轴改善糖尿病肾病。
用添加或不添加 0.4% 白藜芦醇的饲料喂养 db/db 小鼠 12 周,之后对肠道微生物群、粪便短链脂肪酸 (SCFA) 和肾脏纤维化进行分析。白藜芦醇改善了糖尿病肾病的进展,减轻了肾小管间质纤维化。进一步的研究表明,白藜芦醇可调节肠道微生物群失调,其特点是产生 SCFAs 的粪杆菌和乳酸杆菌增多,从而增加了粪便中 SCFAs(尤其是乙酸)的浓度。此外,微生物群移植实验发现,改变肠道微生物群有助于预防糖尿病肾病。醋酸治疗可改善 db/db 小鼠的蛋白尿、肾小球硬化和肾小管间质纤维化。总体而言,白藜芦醇通过抑制肾小管间质纤维化改善了糖尿病肾病的进展,这可能至少部分涉及肠道微生物群-SCFAs轴的调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.50
自引率
2.60%
发文量
60
审稿时长
1 months
期刊介绍: The primary aim of International Journal of Food Sciences and Nutrition is to integrate food science with nutrition. Improvement of knowledge in human nutrition should always be the final objective of submitted research. It''s an international, peer-reviewed journal which publishes high quality, original research contributions to scientific knowledge. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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