Targeting ferroptosis in the maintenance of mitochondrial homeostasis in the realm of septic cardiomyopathy

IF 4 3区 医学 Q1 PHARMACOLOGY & PHARMACY
Hua Ye , Huantao Hu , Xiaoliang Zhou , Maolong Dong , Jun Ren
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引用次数: 0

Abstract

Septic cardiomyopathy is one of the predominant culprit factors contributing to the rising mortality in patients with severe sepsis. Among various mechanisms responsible for the etiology of septic heart anomalies, disruption of mitochondrial homeostasis has gained much recent attention, resulting in myocardial inflammation and even cell death. Ferroptosis is a novel category of regulated cell death (RCD) provoked by iron-dependent phospholipid peroxidation through iron-mediated phospholipid (PL) peroxidation, enroute to the rupture of plasma membranes and eventually cell death. This review summarizes the recent progress of ferroptosis in mitochondrial homeostasis during septic cardiomyopathy. We will emphasize the role of mitochondrial iron transport channels and the antioxidant system in ferroptosis. Finally, we will summarize and discuss future research, which should help guide disease treatment.

在脓毒症心肌病领域,以维持线粒体稳态的铁蛋白沉积为目标
脓毒性心肌病是导致严重脓毒症患者死亡率上升的主要罪魁祸首之一。在导致脓毒症心脏异常的各种病因机制中,线粒体平衡被破坏导致心肌炎症甚至细胞死亡的机制近年来备受关注。铁变态反应是一种新型的调节性细胞死亡(RCD),由铁依赖性磷脂过氧化引起,通过铁介导的磷脂(PL)过氧化,导致质膜破裂,最终导致细胞死亡。本综述总结了脓毒症心肌病过程中线粒体稳态中的铁变态反应的最新进展。我们将强调线粒体铁转运通道和抗氧化系统在铁变态反应中的作用。最后,我们将总结并讨论未来的研究,这将有助于指导疾病的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.80
自引率
2.50%
发文量
131
审稿时长
4-8 weeks
期刊介绍: Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.
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