Effect of sarcopenia on mortality in acute stroke patients receiving endovascular treatment.

IF 1.5 4区医学 Q4 CLINICAL NEUROLOGY

Interventional Neuroradiology Pub Date : 2024-10-01 Epub Date: 2024-01-17 DOI:10.1177/15910199241227465

Muhammed Said Beşler, Nurdan Çay, Bige Sayın

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引用次数: 0

Abstract

Background: To investigate the effect of sarcopenia on mortality in patients with acute ischemic stroke caused by anterior circulation large artery occlusion who underwent endovascular treatment.

Methods: Acute ischemic stroke patients (n = 194) treated with mechanical thrombectomy who underwent chest computed tomography between 2019 and 2022 (median age, 69 [interquartile range: 61-77], 95 females, 99 males) were evaluated retrospectively. The cross-sectional area and density of the pectoralis muscle [pectoralis muscle area (PMA) and pectoralis muscle density (PMD)] at the level of the aortic arch and the erector spinae muscle at the T12 level [erector spinae muscle area (ESMA) and erector spinae muscle density (ESMD)] were measured. The association between skeletal muscle parameters and mortality outcomes was investigated using the receiver operating characteristic (ROC) curve and multivariable logistic regression analyses.

Results: The 90-day mortality rate was 32% in the study population (n = 62). The ROC analysis revealed that ESMD [area under the curve (AUC): 0.765] and PMD (AUC: 0.759) performed best in the prediction of 90-day mortality. In the multivariable logistic regression analysis, PMD [odds ratio (OR): 0.896; 95% confidence interval (CI): 0.846-0.948; p < 0.001], ESMA (OR: 0.929; 95% CI: 0.878-0.983; p = 0.011), and ESMD (OR: 0.947; 95% CI: 0.913-0.983; p = 0.004), but not PMA, were independent risk factors for 90-day mortality.

Conclusion: PMD, ESMA, and ESMD may be risk factors for 90-day mortality after mechanical thrombectomy for acute ischemic stroke.

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肌肉疏松症对接受血管内治疗的急性中风患者死亡率的影响。

背景：研究肌肉疏松症对接受血管内治疗的前循环大动脉闭塞所致急性缺血性脑卒中患者死亡率的影响：目的：研究肌肉疏松症对接受血管内治疗的前循环大动脉闭塞引起的急性缺血性卒中患者死亡率的影响：对2019年至2022年期间接受胸部计算机断层扫描的接受机械取栓术治疗的急性缺血性卒中患者（n = 194）（中位年龄69岁[四分位间范围：61-77]，女性95人，男性99人）进行回顾性评估。研究人员测量了主动脉弓水平的胸肌横截面积和密度[胸肌面积（PMA）和胸肌密度（PMD）]以及T12水平的竖脊肌横截面积和密度[竖脊肌面积（ESMA）和竖脊肌密度（ESMD）]。采用接收器操作特征曲线（ROC）和多变量逻辑回归分析研究了骨骼肌参数与死亡率之间的关系：研究对象（n = 62）的 90 天死亡率为 32%。ROC分析显示，ESMD[曲线下面积（AUC）：0.765]和PMD（AUC：0.759）在预测90天死亡率方面表现最佳。在多变量逻辑回归分析中，PMD[几率比（OR）：0.896；95% 置信区间（CI）：0.846-0.948；P = 0.011]和ESMD（OR：0.947；95% CI：0.913-0.983；P = 0.004）是90天死亡率的独立危险因素，而不是PMA：结论：PMD、ESMA 和 ESMD 可能是急性缺血性卒中机械取栓术后 90 天死亡率的风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Interventional Neuroradiology CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

3.60

自引率

11.80%

发文量

192

审稿时长

6-12 weeks

期刊介绍： Interventional Neuroradiology (INR) is a peer-reviewed clinical practice journal documenting the current state of interventional neuroradiology worldwide. INR publishes original clinical observations, descriptions of new techniques or procedures, case reports, and articles on the ethical and social aspects of related health care. Original research published in INR is related to the practice of interventional neuroradiology...