Effects of N-acetylcysteine on spexin immunoreactivity in kidney tissues of rats treated with adriamycin.

IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Tuba Yalçin, Tuncay Kuloğlu, Nalan Kaya Tektemur, Ahmet Tektemur, İbrahim Enver Ozan
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引用次数: 0

Abstract

Objectives: Due to its negative side effects, mainly nephrotoxicity, adriamycin (ADR) is used fairly infrequently. The purpose of this study is to investigate the effects of N-acetyl cysteine (NAC) on the immunoreactivity of spexin (SPX) in the kidney tissues of rats given ADR.

Materials and methods: A total of 28 male Sprague-Dawley rats were randomly assigned to four groups (n=7): control (no intervention), NAC (150 mg/kg/day, administered intraperitoneally), ADR (single dose of 15 mg/kg, administered intraperitoneally), and ADR+NAC (single dose of 15 mg/kg ADR + 150 mg/kg/day NAC, both administered intraperitoneally). The experiment was concluded on the 15th day.

Results: The administration of ADR resulted in biochemical and histopathological alterations in the kidney. It was found that ADR treatment led to elevated levels of TOS (total oxidative stress), apoptosis, and SPX. Conversely, when NAC was administered as a treatment, it effectively reduced TOS, apoptosis, and SPX levels. These findings suggest that SPX may contribute to the development of ADR-induced kidney damage.

Conclusion: Further investigations are warranted to gain a comprehensive understanding of kidney damage, and specifically to elucidate the role of SPX in this context. Additionally, these studies can pave the way for exploring novel therapeutic strategies targeting SPX to prevent and/or treat the development of kidney damage.

N-乙酰半胱氨酸对阿霉素治疗大鼠肾组织中矛毒素免疫反应的影响
目的:由于阿霉素(ADR)的副作用(主要是肾毒性),它已很少被使用。本研究旨在探讨 N-乙酰半胱氨酸(NAC)对服用 ADR 的大鼠肾组织中 spexin(SPX)免疫反应的影响:将28只雄性Sprague-Dawley大鼠随机分为四组(n=7):对照组(无干预)、NAC组(150毫克/千克/天,腹腔给药)、ADR组(单剂量15毫克/千克,腹腔给药)和ADR+NAC组(单剂量15毫克/千克ADR+150毫克/千克/天NAC,均腹腔给药)。实验于第 15 天结束:结果:服用 ADR 会导致肾脏的生化和组织病理学改变。结果发现,ADR 会导致 TOS(总氧化应激)、细胞凋亡和 SPX 水平升高。相反,当使用 NAC 作为治疗时,它能有效降低 TOS、细胞凋亡和 SPX 水平。这些研究结果表明,SPX 可能是 ADR 引起肾损伤的原因之一:结论:为了全面了解肾损伤,特别是阐明 SPX 在肾损伤中的作用,有必要开展进一步的研究。此外,这些研究还能为探索针对 SPX 的新型治疗策略铺平道路,从而预防和/或治疗肾损伤的发生。
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来源期刊
Iranian Journal of Basic Medical Sciences
Iranian Journal of Basic Medical Sciences MEDICINE, RESEARCH & EXPERIMENTAL-PHARMACOLOGY & PHARMACY
CiteScore
4.00
自引率
4.50%
发文量
142
审稿时长
6-12 weeks
期刊介绍: The Iranian Journal of Basic Medical Sciences (IJBMS) is a peer-reviewed, monthly publication by Mashhad University of Medical Sciences (MUMS), Mashhad, Iran . The Journal of "IJBMS” is a modern forum for scientific communication. Data and information, useful to investigators in any discipline in basic medical sciences mainly including Anatomical Sciences, Biochemistry, Genetics, Immunology, Microbiology, Pathology, Pharmacology, Pharmaceutical Sciences, and Physiology, will be published after they have been peer reviewed. This will also include reviews and multidisciplinary research.
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