Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability.

IF 2.7 4区 医学 Q1 ORTHOPEDICS
CARTILAGE Pub Date : 2024-12-01 Epub Date: 2024-01-18 DOI:10.1177/19476035231221211
Sheena Devasia, Jinu T Joseph, Stephena P S, Seiko Koizumi, Liz Clarke, Sriraam V T, Abhilash Parameswaran Kailas, Shajil Madhavan
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引用次数: 0

Abstract

Objective: The various functionalities of collagen peptides have generated a large interest in utilizing the bioactive peptides as a nutritional therapy to ameliorate various physiological degenerative conditions. Collagen peptides are observed to reduce the pain and aligned difficulties with respect to osteoarthritis. Here we report the enhanced ameliorating property of novel high-functional "Wellnex" Type J collagen peptides following a double-blind randomized active and placebo-controlled 5-arm clinical trial (n = 100) by using it as a nutritional supplement in subjects with knee joint osteoarthritis in comparison with conventional bovine collagen peptides. The efficacy, safety, and tolerability were also studied.

Design: Dosages of 2.5, 5.0, and 10.0 g of high-functional Type J bovine collagen peptides, 10.0 g of conventional collagen peptides, and 10.0 g of placebo were given to the 5 groups for a period of 90 days. The Western Ontario McMaster Universities Arthritis Index (WOMAC) score, Pain Scale, Quality of Life (QoL), Physician's Impression of change Score (PICS), serum C-terminal cross-linked telopeptide of type II collagen (CTX-II) levels and Magnetic Resonance Imaging Osteoarthritis Knee Score (MOAKS) parameters were monitored.

Results: Type J 2.5 g showed significant improvement in WOMAC, QoL, CTX, and MOAKS and observed to be equivalent to conventional collagen peptide 10-g supplementation in terms of efficacy.

Conclusion: The two significant outcomes of the study were that Type J 10.0 g, Type J 5.0 g, Type J 2.5 g and conventional collagen peptides 10.0 g supplementation were observed to be beneficial nutraceutical therapies for knee joint osteoarthritis, and Type J 2.5 g supplementation was equivalent to conventional collagen peptides 10.0-g supplementation in terms of efficacy.

使用新型高功能牛胶原蛋白肽作为营养疗法治疗和改善成人膝关节骨关节炎:一项评估疗效、安全性和耐受性的双盲、前瞻性、多中心、随机、活性和安慰剂对照、五臂临床研究。
目的:胶原蛋白肽的各种功能使人们对利用生物活性肽作为营养疗法来改善各种生理退行性病症产生了浓厚的兴趣。据观察,胶原蛋白肽可减轻骨关节炎的疼痛和排列困难。与传统的牛胶原蛋白肽相比,新型高功能 "Wellnex "J 型胶原蛋白肽作为膝关节骨关节炎受试者的营养补充剂,在双盲随机、积极和安慰剂对照的 5 臂临床试验(n = 100)中具有更强的改善特性。此外,还对其疗效、安全性和耐受性进行了研究:设计:5 组分别服用 2.5 克、5.0 克和 10.0 克高功能 J 型牛胶原蛋白肽、10.0 克常规胶原蛋白肽和 10.0 克安慰剂,为期 90 天。对西安大略麦克马斯特大学关节炎指数(WOMAC)评分、疼痛量表、生活质量(QoL)、医生变化印象评分(PICS)、血清 II 型胶原蛋白 C 端交联端肽(CTX-II)水平和磁共振成像骨关节炎膝关节评分(MOAKS)参数进行了监测:结果:J型2.5克胶原蛋白对WOMAC、QoL、CTX和MOAKS有明显改善,在疗效方面与传统胶原蛋白肽10克补充剂相当:该研究的两个重要结果是,J型10.0克、J型5.0克、J型2.5克和传统胶原蛋白肽10.0克补充剂被认为是对膝关节骨关节炎有益的营养保健疗法,而J型2.5克补充剂在疗效方面与传统胶原蛋白肽10.0克补充剂相当。
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来源期刊
CARTILAGE
CARTILAGE ORTHOPEDICS-
CiteScore
6.90
自引率
7.10%
发文量
80
期刊介绍: CARTILAGE publishes articles related to the musculoskeletal system with particular attention to cartilage repair, development, function, degeneration, transplantation, and rehabilitation. The journal is a forum for the exchange of ideas for the many types of researchers and clinicians involved in cartilage biology and repair. A primary objective of CARTILAGE is to foster the cross-fertilization of the findings between clinical and basic sciences throughout the various disciplines involved in cartilage repair. The journal publishes full length original manuscripts on all types of cartilage including articular, nasal, auricular, tracheal/bronchial, and intervertebral disc fibrocartilage. Manuscripts on clinical and laboratory research are welcome. Review articles, editorials, and letters are also encouraged. The ICRS envisages CARTILAGE as a forum for the exchange of knowledge among clinicians, scientists, patients, and researchers. The International Cartilage Repair Society (ICRS) is dedicated to promotion, encouragement, and distribution of fundamental and applied research of cartilage in order to permit a better knowledge of function and dysfunction of articular cartilage and its repair.
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