Macrostructure and Microenvironment Biomimetic Hydrogel: Design, Properties, and Tissue Engineering Application

IF 7 2区材料科学 Q2 CHEMISTRY, PHYSICAL

Chemistry of Materials Pub Date : 2024-01-16 DOI:10.1021/acs.chemmater.3c02098

Shufeng Hu, Chen Zeng, Yuchen Jiang, Weiqing Kong* and Meifang Zhu,

{"title":"Macrostructure and Microenvironment Biomimetic Hydrogel: Design, Properties, and Tissue Engineering Application","authors":"Shufeng Hu, Chen Zeng, Yuchen Jiang, Weiqing Kong* and Meifang Zhu, ","doi":"10.1021/acs.chemmater.3c02098","DOIUrl":null,"url":null,"abstract":"<p >The field of tissue engineering and regenerative medicine is rapidly advancing, with numerous novel and intriguing biomimetic materials being reported. Hydrogels, due to their unique structure and properties closely resembling biological tissues, stand as prime candidates for mimicking natural tissues in tissue engineering and regenerative medicine applications. In recent years, drawing inspiration from the intricate structures found in biological soft tissues, researchers have successfully created a range of biomimetic hydrogels. These hydrogels have been tailored for diverse applications in fields such as biomedicine, tissue engineering, flexible electronic devices, and beyond. However, designing and fabricating biomimetic synthetic materials with intricate structures, dynamic microenvironment systems, and integrated functionalities remains challenging. This article presents the latest research progress in macroscopic structural biomimetic hydrogels, as well as microenvironment biomimetic hydrogels, along with the most recent construction strategies, key design principles, and optimization mechanisms. It summarizes their potential applications in various domains such as tissue repair, signal detection and sensing, drug delivery, and more. Lastly, the challenges and future development directions in the preparation and application of biomimetic hydrogels are outlined.</p>","PeriodicalId":33,"journal":{"name":"Chemistry of Materials","volume":"36 3","pages":"1054–1087"},"PeriodicalIF":7.0000,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Materials","FirstCategoryId":"88","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.chemmater.3c02098","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

The field of tissue engineering and regenerative medicine is rapidly advancing, with numerous novel and intriguing biomimetic materials being reported. Hydrogels, due to their unique structure and properties closely resembling biological tissues, stand as prime candidates for mimicking natural tissues in tissue engineering and regenerative medicine applications. In recent years, drawing inspiration from the intricate structures found in biological soft tissues, researchers have successfully created a range of biomimetic hydrogels. These hydrogels have been tailored for diverse applications in fields such as biomedicine, tissue engineering, flexible electronic devices, and beyond. However, designing and fabricating biomimetic synthetic materials with intricate structures, dynamic microenvironment systems, and integrated functionalities remains challenging. This article presents the latest research progress in macroscopic structural biomimetic hydrogels, as well as microenvironment biomimetic hydrogels, along with the most recent construction strategies, key design principles, and optimization mechanisms. It summarizes their potential applications in various domains such as tissue repair, signal detection and sensing, drug delivery, and more. Lastly, the challenges and future development directions in the preparation and application of biomimetic hydrogels are outlined.

Abstract Image

查看原文本刊更多论文

宏观结构与微环境仿生水凝胶：设计、特性与组织工程应用

组织工程和再生医学领域的发展日新月异，许多新颖奇特的生物仿生材料不断涌现。水凝胶因其独特的结构和与生物组织极为相似的特性，成为组织工程和再生医学应用中模拟天然组织的主要候选材料。近年来，研究人员从生物软组织的复杂结构中汲取灵感，成功制造出一系列仿生物水凝胶。这些水凝胶被定制用于生物医学、组织工程、柔性电子设备等领域的各种应用。然而，设计和制造具有复杂结构、动态微环境系统和集成功能的仿生物合成材料仍然充满挑战。本文介绍了宏观结构仿生水凝胶和微环境仿生水凝胶的最新研究进展，以及最新的构建策略、关键设计原理和优化机制。报告总结了它们在组织修复、信号检测和传感、药物输送等各个领域的潜在应用。最后，概述了仿生水凝胶的制备和应用所面临的挑战和未来的发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Chemistry of Materials 工程技术-材料科学：综合

CiteScore

14.10

自引率

5.80%

发文量

929

审稿时长

1.5 months

期刊介绍： The journal Chemistry of Materials focuses on publishing original research at the intersection of materials science and chemistry. The studies published in the journal involve chemistry as a prominent component and explore topics such as the design, synthesis, characterization, processing, understanding, and application of functional or potentially functional materials. The journal covers various areas of interest, including inorganic and organic solid-state chemistry, nanomaterials, biomaterials, thin films and polymers, and composite/hybrid materials. The journal particularly seeks papers that highlight the creation or development of innovative materials with novel optical, electrical, magnetic, catalytic, or mechanical properties. It is essential that manuscripts on these topics have a primary focus on the chemistry of materials and represent a significant advancement compared to prior research. Before external reviews are sought, submitted manuscripts undergo a review process by a minimum of two editors to ensure their appropriateness for the journal and the presence of sufficient evidence of a significant advance that will be of broad interest to the materials chemistry community.