Severe Hypertensive Response to Atropine Therapy for Bradycardia Associated with Dexmedetomidine: Case Report and Literature Review.

IF 3.1 Q2 PHARMACOLOGY & PHARMACY
Clinical Pharmacology : Advances and Applications Pub Date : 2024-01-11 eCollection Date: 2024-01-01 DOI:10.2147/CPAA.S436188
Yong Li, Ju Gao, Lin Jiang, Canlin Sun, Hua Hong, Dapeng Yu
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引用次数: 0

Abstract

Dexmedetomidine is a selective and potent α2-adrenoceptor agonist used for sedation, analgesia, and anxiolysis, with minimal respiratory depression; therefore, it is widely used in clinical practice. Transient hypertension has been reported to be an indication for the use of dexmedetomidine. The authors report three female patients who experienced hypertensive crisis when used atropine to treat bradycardia caused by dexmedetomidine. The transient hypertension is a relatively common side effect of dexmedetomidine, hypertensive crisis seen with coadministration of atropine is much less frequently reported. This is the first report to describe the use of atropine to treat bradycardia induced by dexmedetomidine, which may cause severe hypertension in female patients. They discuss the reason for and treatment of hypertension caused by administration of atropine and dexmedetomidine together and review the relevant literature.

阿托品治疗右美托咪定引起的心动过缓的严重高血压反应:病例报告和文献综述。
右美托咪定是一种选择性强效α2-肾上腺素受体激动剂,可用于镇静、镇痛和抗焦虑,呼吸抑制作用极小,因此被广泛应用于临床。据报道,一过性高血压是使用右美托咪定的适应症之一。作者报告了三名女性患者在使用阿托品治疗右美托咪定引起的心动过缓时出现高血压危象。一过性高血压是右美托咪定比较常见的副作用,而联合使用阿托品时出现高血压危象的报道要少得多。这是第一份描述使用阿托品治疗右美托咪定引起的心动过缓的报告,心动过缓可能导致女性患者出现严重的高血压。他们讨论了同时使用阿托品和右美托咪定引起高血压的原因和治疗方法,并回顾了相关文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
14
审稿时长
16 weeks
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