Molecular genetic association of rs8099917 and rs1800795 polymorphisms in the progression of hepatitis Delta virus liver disease.

IF 1.8 3区医学 Q4 TOXICOLOGY

Journal of Venomous Animals and Toxins Including Tropical Diseases Pub Date : 2024-01-12 eCollection Date: 2024-01-01 DOI:10.1590/1678-9199-JVATITD-2023-0025

Ana Maísa Passos-Silva, Eugênia de Castro E Silva, Lourdes Maria Pinheiro Borzacov, Adrhyan Araújo, Anita Sperandio Porto, Juan Miguel Villalobos Salcedo, Deusilene Vieira

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Abstract

Background: The relationship between viral infections and host factors holds high hopes for identifying the role of Interferon Lambda 3 (IFNL3) and Interleukin 6 (IL-6) polymorphisms in the development of Chronic Liver Disease (CLD) in patients infected with hepatitis Delta virus (HDV) in the Western Brazilian Amazon.

Methods: Cross-sectional study conducted with a cohort of 40 chronic HDV patients, 27 with CLD and 13 without evident liver damage. Biological samples from the participants were analyzed using the polymerase chain reaction (PCR) technique, followed by sequencing by the automated Sanger method.

Results: The rs8099917 T allele, from the IFNL3 gene, showed a higher frequency in both groups; however, it was not possible to establish an association with HDV infection [OR = 1.42 (0.42 - 4.75; p = 0.556 (95% CI). For IL-6, the rs1800795 G allele was superior to rs1800795 C. Analyzing both distributions in the studied groups, any association with HDV was absent (p > 0.05).

Conclusion: The results suggest that the rs8099917 T/G (IFNL3) and rs1800795 G/C (IL-6) polymorphisms are not associated with the evolution of HDV in the studied population.

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rs8099917和rs1800795多态性与三角洲肝炎病毒肝病进展的分子遗传学关联。

背景：病毒感染与宿主因素之间的关系为确定干扰素λ3（IFNL3）和白细胞介素6（IL-6）多态性在巴西亚马孙河流域西部感染三角洲肝炎病毒（HDV）的患者发展为慢性肝病（CLD）中的作用带来了很大希望：对 40 名慢性 HDV 患者进行横断面研究，其中 27 人患有慢性肝病，13 人无明显肝损伤。采用聚合酶链反应（PCR）技术对参与者的生物样本进行分析，然后采用自动桑格方法进行测序：IFNL3基因中的rs8099917 T等位基因在两组中的频率都较高；但无法确定与HDV感染的关系[OR = 1.42 (0.42 - 4.75; p = 0.556 (95% CI)。对研究组中的两种分布进行分析后发现，IL-6的rs1800795 G等位基因优于rs1800795 C等位基因：结果表明，在研究人群中，rs8099917 T/G（IFNL3）和 rs1800795 G/C（IL-6）多态性与 HDV 的演变无关。

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来源期刊

Journal of Venomous Animals and Toxins Including Tropical Diseases 医学-毒理学

CiteScore

4.80

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Venomous Animals and Toxins including Tropical Diseases (JVATiTD) is a non-commercial academic open access publication dedicated to research on all aspects of toxinology, venomous animals and tropical diseases. Its interdisciplinary content includes original scientific articles covering research on toxins derived from animals, plants and microorganisms. Topics of interest include, but are not limited to:systematics and morphology of venomous animals;physiology, biochemistry, pharmacology and immunology of toxins;epidemiology, clinical aspects and treatment of envenoming by different animals, plants and microorganisms;development and evaluation of antivenoms and toxin-derivative products;epidemiology, clinical aspects and treatment of tropical diseases (caused by virus, bacteria, algae, fungi and parasites) including the neglected tropical diseases (NTDs) defined by the World Health Organization.

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