Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biological Trace Element Research Pub Date : 2024-11-01 Epub Date: 2024-01-15 DOI:10.1007/s12011-024-04059-x

Mahsa Khajeh, Shirin Hassanizadeh, Fatemeh Pourteymour Fard Tabrizi, Reza Hassanizadeh, Mahdi Vajdi, Gholamreza Askari

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引用次数: 0

Abstract

The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) is to investigate the overall effects of zinc supplementation on lipid profile and body composition such as body weight (BW), body mass index (BMI), triglycerides (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C) in patients with type 2 diabetes mellitus (T2DM). Scopus, Web of Science, PubMed, and Embase databases were searched from inception through October, 2023. The I² and Cochran's Q tests were used to assess heterogeneity between studies. Nineteen RCTs (n = 1357 participants) were included in the meta-analysis. Zinc supplementation significantly reduced TG (WMD = - 17.41 mg/dL; 95% CI: - 22.60, - 12.22; P < 0.001), TC (WMD: - 19.60 mg/dL; 95% CI: - 28.46, - 10.73, P < 0.001), LDL-C (WMD = - 8.80 mg/dL; 95% CI: - 14.80, - 2.81; P = 0.004), and BMI (WMD = - 0.53 kg/m²; 95% CI: - 1.05, - 0.01; P = 0.046) but not BW (WMD: - 0.51 kg, 95 % CI: - 1.99, 0.97, P = 0.498). Moreover, zinc supplementation increased HDL-C (WMD = 4.82 mg/dL; 95% CI: 0.88, 8.76; P = 0.016) in patients with T2DM. Our results propose that zinc supplementation may be an effective strategy for improving lipid profile and body composition in patients with T2DM.

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补锌对 2 型糖尿病患者血脂组合和身体组成的影响：GRADE评估的系统综述和剂量反应荟萃分析》。

本系统综述和随机对照试验 (RCT) 的荟萃分析旨在研究补锌对 2 型糖尿病 (T2DM) 患者的血脂状况和身体组成，如体重 (BW)、体重指数 (BMI)、甘油三酯 (TG)、总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL-C) 和高密度脂蛋白胆固醇 (HDL-C) 的总体影响。对 Scopus、Web of Science、PubMed 和 Embase 数据库进行了检索，检索期从开始到 2023 年 10 月。采用 I2 和 Cochran's Q 检验来评估研究之间的异质性。荟萃分析中纳入了 19 项 RCT 研究（n = 1357 名参与者）。补锌可明显降低 TG（WMD = - 17.41 mg/dL；95% CI：- 22.60，- 12.22；P <0.001）、TC（WMD：- 19.60 mg/dL；95% CI：- 28.46，- 10.73，P <0.001）、LDL-C（WMD = - 8.80 mg/dL; 95% CI: - 14.80, - 2.81; P = 0.004）和体重指数（WMD = - 0.53 kg/m2; 95% CI: - 1.05, - 0.01; P = 0.046），但体重没有增加（WMD: - 0.51 kg, 95 % CI: - 1.99, 0.97, P = 0.498）。此外，补锌可提高 T2DM 患者的 HDL-C（WMD = 4.82 mg/dL；95% CI：0.88，8.76；P = 0.016）。我们的研究结果表明，补锌可能是改善 T2DM 患者血脂状况和身体组成的有效策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Trace Element Research 生物-内分泌学与代谢

CiteScore

8.70

自引率

10.30%

发文量

459

审稿时长

2 months

期刊介绍： Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.