Revitalizing Ancient Mitochondria with Nano-Strategies: Mitochondria-Remedying Nanodrugs Concentrate on Disease Control

IF 27.4 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Xingyu Long, Min Liu, Yayun Nan, Qiaohui Chen, Zuoxiu Xiao, Yuting Xiang, Xiaohong Ying, Jian Sun, Qiong Huang, Kelong Ai
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Abstract

Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad of vital functions across diverse cellular processes. Dysfunctions within mitochondria serve as catalysts for various diseases, prompting widespread cellular demise. Mounting research on remedying damaged mitochondria indicates that mitochondria constitute a valuable target for therapeutic intervention against diseases. But the less clinical practice and lower recovery rate imply the limitation of traditional drugs, which need a further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution and high efficacy by capitalizing on excellent nanomaterials and targeting drug delivery. Mitochondria-remedying nanodrugs have achieved ideal therapeutic effects. This review elucidates the significance of mitochondria in various cells and organs, while also compiling mortality data for related diseases. Correspondingly, nanodrug-mediate therapeutic strategies and applicable mitochondria-remedying nanodrugs in disease are detailed, with a full understanding of the roles of mitochondria dysfunction and the advantages of nanodrugs. In addition, the future challenges and directions are widely discussed. In conclusion, this review provides comprehensive insights into the design and development of mitochondria-remedying nanodrugs, aiming to help scientists who desire to extend their research fields and engage in this interdisciplinary subject.

Abstract Image

用纳米战略振兴古老的线粒体:线粒体修复纳米药物专注于疾病控制。
众所周知,线粒体是真核细胞的能量工厂,在各种细胞过程中发挥着无数重要功能。线粒体功能失调是各种疾病的催化剂,会导致广泛的细胞死亡。有关修复受损线粒体的研究日益增多,表明线粒体是治疗干预疾病的重要靶点。但临床实践较少,治愈率较低,这意味着传统药物的局限性,需要进一步突破。纳米技术利用优异的纳米材料和靶向给药技术,实现了良好的区域特异性生物分布和高效药效。线粒体修复纳米药物取得了理想的治疗效果。在这篇综述中,我们阐明了线粒体在各种细胞和器官中的重要性,同时还整理了相关疾病的死亡率数据。在充分了解线粒体功能障碍的作用和纳米药物的优势的基础上,详细介绍了纳米药物介导的治疗策略和适用于疾病的线粒体修复纳米药物。此外,还广泛讨论了未来的挑战和方向。总之,这篇综述对线粒体修复纳米药物的设计和开发提供了全面的见解,旨在帮助有志于扩展研究领域和从事这一交叉学科研究的科学家。本文受版权保护。保留所有权利。
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来源期刊
Advanced Materials
Advanced Materials 工程技术-材料科学:综合
CiteScore
43.00
自引率
4.10%
发文量
2182
审稿时长
2 months
期刊介绍: Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.
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