PLGA - gallic Acid Advanced Drug Delivery System as New Functional Material

IF 0.6 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materiale Plastice Pub Date : 2024-01-05 DOI:10.37358/mp.23.4.5688

Anne-Marie Beatrice Poenariu, Roberto Angelo Postelnicu, M. Ciocîlteu, Gabriela Rau, Mariana Popescu, A. Simionescu, Ionela Andreea Neacsu, C. Nicolicescu, D. Amzoiu

引用次数: 0

Abstract

Combining polimers with polyphenols such as gallic acid opens up new directions in healthcare system. By encapsulating secondary metabollites within PLGA nanoparticles, we tried to enhance their stability, solubility, and obtain a targeted delivery system. In this study, we synthesized a PLGA-gallic acid sustained release system, using the solvent evaporation method. This approach improved the therapeutic efficacy of gallic acid. The numerical distribution showed that most PLGA-GA nanoparticles have a size of 10 nm. Through the method of solvent evaporation, an incorporation efficiency of 49% was obtained.

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作为新型功能材料的聚乳酸-没食子酸高级给药系统

将多聚物与没食子酸等多酚类物质相结合为医疗保健系统开辟了新方向。通过在聚乳酸（PLGA）纳米颗粒中封装次生代谢产物，我们试图提高它们的稳定性和可溶性，并获得一种靶向给药系统。在这项研究中，我们采用溶剂蒸发法合成了聚乳酸-胆酸缓释系统。这种方法提高了没食子酸的疗效。数值分布显示，大多数 PLGA-GA 纳米粒子的尺寸为 10 nm。通过溶剂蒸发法，获得了 49% 的掺入效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materiale Plastice MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

1.40

自引率

25.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Materiale Plastice, abbreviated as Mater. Plast., publishes original scientific papers or guest reviews on topics of great interest. The Journal does not publish memos, technical reports or non-original papers (that are a compiling of literature data) or papers that have been already published in other national or foreign Journal.