Chemotactic nanomotor for multimodal combined therapy of glioblastoma

IF 10.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Science China Chemistry Pub Date : 2024-01-08 DOI:10.1007/s11426-023-1837-7

Ting Li, Lin Chen, Yunxin Xue, Xiangyu Xiao, Wenjun Dai, Kaiyuan Tan, Tiantian Chen, Yingfang Tao, Chun Mao, Jian Shen, Mimi Wan

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引用次数: 0

Abstract

Glioblastoma (GBM) is the most aggressive malignant brain tumor. Due to the infiltration and heterogeneity of GBM, the obstruction of the blood-brain barrier (BBB) and the unique immunosuppressive mechanism, it is hard to achieve significant effects of GBM treatment. Here, a kind of chemotactic nanomotor that loaded with glucose oxidase (GOx) and carboxylated cisplatin (Pt(IV)) prodrug on the L-arginine-derived polymer is proposed. The nanomotors are driven by catalysis of glucose decomposition and the positive chemotaxis towards the GBM microenvironment where inducible nitric oxide synthase and reactive oxygen species are highly expressed. This facilitates the BBB crossing and GBM targeting of the nanomotors. In addition, the released nitric oxide (NO) during propulsion as well as the loaded GOx and Pt(IV) can exert combined NO/starvation/chemotherapy. Meanwhile, it is able to induce and enhance the immune response through multiple pathways, thus better coping with the complexities of GBM treatment.

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用于胶质母细胞瘤多模式联合疗法的化疗纳米马达

胶质母细胞瘤（GBM）是侵袭性最强的恶性脑肿瘤。由于GBM的浸润性和异质性、血脑屏障（BBB）的阻塞性以及独特的免疫抑制机制，GBM的治疗很难取得显著效果。本文提出了一种在L-精氨酸衍生聚合物上负载葡萄糖氧化酶（GOx）和羧化顺铂（Pt(IV)）原药的趋化纳米马达。纳米马达由葡萄糖分解催化和向诱导性一氧化氮合酶和活性氧高度表达的 GBM 微环境的正趋化驱动。这有助于纳米马达穿过 BBB 和靶向 GBM。此外，推进过程中释放的一氧化氮（NO）以及负载的 GOx 和 Pt(IV)可以发挥 NO/饥饿/化疗的综合作用。同时，它还能通过多种途径诱导和增强免疫反应，从而更好地应对复杂的 GBM 治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science China Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

7.30%

发文量

3787

审稿时长

2.2 months

期刊介绍： Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field. Categories of articles include: Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry. Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies. Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.