The Association of Body Mass Index with Cognition and Alzheimer’s Disease Biomarkers in the Elderly with Different Cognitive Status: A Study from the Alzheimer’s Disease Neuroimaging Initiative Database

IF 2.8 Q2 NEUROSCIENCES

Journal of Alzheimer's disease reports Pub Date : 2024-01-09 DOI:10.3233/adr-230163

Qin Li, Jiehong Zhan, Yu-Ping Feng, Zixuan Liao, Xiaofeng Li

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Abstract

Background: The association of body mass index (BMI) with cognition and Alzheimer’s disease (AD) biomarkers of the elderly remains inconclusive. Objective: To investigate the relationship between BMI and cognition as well as AD biomarkers in the elderly with different cognitive status. Methods: Participants with cognitively normal (CN) were included as the CN group. Participants with mild cognitive impairment and mild dementia were included as the cognitive impairment (CI) group. The relationship between BMI and AD biomarkers (cerebrospinal fluid Aβ42 and p-tau181, hippocampal volume [HV]), global cognition (Mini-Mental State Examination [MMSE]), memory, and executive function were explored. Results: In the CI group, BMI was associated with MMSE (β= 0.03, p = 0.009), Aβ42 (β= 0.006, p = 0.029), p-tau181/Aβ42 ratio (β= -0.001, p = 0.011), and HV (β= 0.05, p < 0.001). However in the CN group, BMI exhibited associations with p-tau181 (β= 0.012, p = 0.014) and memory composite score (β= -0.04, p = 0.038), but not with p-tau181/Aβ42 ratio and HV. Moreover, mediation analysis showed that in the CI group, the positive effect of BMI on HV and MMSE score was partially mediated by diastolic blood pressure. Conclusion: The association of BMI with cognition and AD biomarkers varies across different cognitive status. In particular, a lower BMI was associated with worse cognition, higher Aβ burden, and lower HV in individuals with CI. Clinical practice should strengthen the monitoring and management of BMI in patients with AD.

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不同认知状况老年人的体重指数与认知和阿尔茨海默病生物标志物的关系：阿尔茨海默病神经影像学倡议数据库研究

背景：体重指数（BMI）与老年人认知能力和阿尔茨海默病（AD）生物标志物的关系仍无定论。目的：探讨体重指数与认知能力以及阿尔茨海默病生物标志物之间的关系：研究不同认知状况的老年人的体重指数与认知能力及阿尔茨海默病生物标志物之间的关系。研究方法将认知正常（CN）的参与者作为 CN 组。轻度认知障碍和轻度痴呆的参与者为认知障碍（CI）组。探讨体重指数与老年痴呆症生物标志物（脑脊液Aβ42和p-tau181、海马体积[HV]）、整体认知（迷你精神状态检查[MMSE]）、记忆和执行功能之间的关系。结果显示在 CI 组中，BMI 与 MMSE（β= 0.03，p = 0.009）、Aβ42（β= 0.006，p = 0.029）、p-tau181/Aβ42 比率（β= -0.001，p = 0.011）和 HV（β= 0.05，p <0.001）相关。然而，在 CN 组中，BMI 与 p-tau181 （β= 0.012，p = 0.014）和记忆综合评分（β= -0.04，p = 0.038）相关，但与 p-tau181/Aβ42 比率和 HV 无关。此外，中介分析表明，在 CI 组中，BMI 对 HV 和 MMSE 评分的积极影响部分由舒张压中介。结论在不同的认知状态下，体重指数与认知能力和注意力缺失症生物标志物的关系各不相同。特别是，在 CI 患者中，较低的 BMI 与较差的认知能力、较高的 Aβ 负担和较低的 HV 相关。临床实践应加强对AD患者BMI的监测和管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's disease reports

CiteScore

2.80

自引率

0.00%

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