The Effects of Physical Activity on Experimental Models of Vascular Dementia: A Systematic Review and Meta-Analysis

IF 1.8 Q4 NEUROSCIENCES

Annals of Neurosciences Pub Date : 2024-01-10 DOI:10.1177/09727531231192759

I. Biose, W. H. Chastain, Rebecca Solch-Ottaiano, Viktoriya S. Grayson, Hanyun Wang, Somdeb Banerjee, Gregory Bix

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引用次数: 0

Abstract

Background: Physical activity is associated with improved brain health and cognition in humans. However, the validity, range, and quality of evidence for the beneficial outcomes linked to exercise in experimental models of vascular dementia (VaD) have not been evaluated. We performed a systematic review and meta-analysis of studies that assessed the effect of exercise intervention on models of VaD to provide an unbiased and comprehensive determination of the cognitive function and brain morphology benefits of exercise. Summary: A systematic search in three databases as well as study design characteristics and experimental data extraction were completed in December 2021. We investigated the effects of exercise on cognitive function and brain-morphology outcomes in VaD models. Twenty-five studies were included for systematic review, while 21 studies were included in the meta-analysis. These studies included seven models of VaD in rats (60%, 15 studies), mice (36%, 9 studies), and pigs (4%, 1 study). None of the included studies used aged animals, and the majority of studies (80%) used only male animals. Key Message: Exercise improves cognition but increased neuro-inflammation in VaD models. Exercise improved cognitive function as well as some markers of brain morphology in models of VaD. However, exercise increased anxiety and neuro-inflammatory signals in VaD models. Further, we observed increased reporting anomalies such as a lack of blinding to group treatment or data analysis and randomization of animals to groups. Our report could help in the appropriate design of experimental studies seeking to investigate the effects of exercise as a non-pharmacological intervention on VaD models with a high translational impact.

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体育锻炼对血管性痴呆实验模型的影响：系统回顾与元分析

背景：体育锻炼与人类大脑健康和认知能力的改善有关。然而，在血管性痴呆（VaD）的实验模型中，与运动相关的有益结果的有效性、范围和证据质量尚未得到评估。我们对评估运动干预对血管性痴呆模型影响的研究进行了系统回顾和荟萃分析，以便对运动对认知功能和大脑形态学的益处做出公正、全面的判断。摘要：我们于 2021 年 12 月完成了对三个数据库的系统检索以及研究设计特征和实验数据提取。我们研究了运动对 VaD 模型认知功能和脑形态结果的影响。系统回顾纳入了 25 项研究，荟萃分析纳入了 21 项研究。这些研究包括大鼠（60%，15 项研究）、小鼠（36%，9 项研究）和猪（4%，1 项研究）的七种 VaD 模型。所有纳入的研究均未使用老年动物，且大多数研究（80%）仅使用雄性动物。关键信息：运动可改善 VaD 模型的认知能力，但会增加神经炎症。运动能改善VaD模型的认知功能以及大脑形态的一些标志物。然而，运动增加了VaD模型的焦虑和神经炎症信号。此外，我们还观察到了更多的报告异常，如缺乏对分组治疗或数据分析的盲法以及将动物随机分组。我们的报告有助于适当设计实验研究，以探究运动作为一种非药物干预措施对VaD模型的影响，并具有较高的转化影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Neurosciences NEUROSCIENCES-

CiteScore

2.40

自引率

0.00%

发文量