Impacto de la fragmentación del ADN espermático y la tecnología de microfluidos en los resultados de fecundación in vitro

IF 0.1 Q4 OBSTETRICS & GYNECOLOGY
S. Cívico Vallejos, Y. Cívico Vallejos, B. Hernández Dacruz
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引用次数: 0

Abstract

An accurate diagnosis in infertile patients is key to determine the treatment of choice in an assisted reproduction program. In the case of the male, the initial diagnosis is based on the result of the semen analysis. The semen analysis can detect problems related to the couple's infertility, but it is insufficient for the correct diagnosis of male infertility, since it does not predict the functional capacity of the spermatozoa. In recent years, multiple studies have appeared that relate sperm ADN integrity to fertility. At the same time, IVF laboratories have within their reach new methods of sperm selection, such as microfluidics, which would make it possible to reduce the degree of ADN fragmentation in the sample. In this paper we review the impact of sperm ADN fragmentation and the use of microfluidic devices on IVF outcomes based on a selection of relevant studies published up to February 2023.

精子 DNA 片段和微流控技术对试管婴儿结果的影响
对不育症患者进行准确诊断是确定辅助生殖方案中首选治疗方法的关键。就男性而言,最初的诊断是基于精液分析的结果。精液分析可以发现与夫妇不育有关的问题,但不足以正确诊断男性不育,因为它不能预测精子的功能能力。近年来,已有多项研究将精子 ADN 的完整性与生育能力联系起来。与此同时,试管婴儿实验室也有了新的精子选择方法,如微流体技术,从而有可能降低样本中 ADN 的破碎程度。在本文中,我们根据截至2023年2月发表的部分相关研究,回顾了精子ADN碎片和微流控设备的使用对试管婴儿结果的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.20
自引率
0.00%
发文量
54
期刊介绍: Una excelente publicación para mantenerse al día en los temas de máximo interés de la ginecología de vanguardia. Resulta idónea tanto para el especialista en ginecología, como en obstetricia o en pediatría, y está presente en los más prestigiosos índices de referencia en medicina.
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