Estimation and comparison of the effective dose and lifetime attributable risk of thyroid cancer between males and females in routine head computed tomography scans: a multicentre study

IF 1.8 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Medical Radiation Sciences Pub Date : 2024-01-12 DOI:10.1002/jmrs.752

Daryoush Khoramian MSc, Mohammad Haghparast MSc, PhD, Adnan Honardari MSc, Ebrahim Nouri MSc, Esmail Ranjbar MSc, Razagh Abedi-Friouzjah MSc, Shiva Zarifi MSc, Choirul Anam Msc, PhD, Milad Najafzadeh MSc, PhD, Mahdieh Afkhami-Ardakni MSc

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引用次数: 0

Abstract

Introduction

A significant number of head computed tomography (CT) scans are performed annually. However, due to the close proximity of the thyroid gland to the radiation field, this procedure can expose the gland to ionising radiation. Consequently, this study aimed to estimate organ dose, effective dose (ED) and lifetime attributable risk (LAR) of thyroid cancer from head CT scans in adults.

Methods

Head CT scans of 74 patients (38 males and 36 females) were collected using three different CT scanners. Age, sex, and scanning parameters, including scan length, tube current–time product (mAs), pitch, CT dose index, and dose-length product (DLP) were collected. CT-Expo software was used to calculate thyroid dose and ED for each patient based on scan parameters. LARs were subsequently computed using the methodology presented in the Biologic Effects of Ionizing Radiation (BEIR) Phase VII report.

Results

Although the mean thyroid organ dose (2.66 ± 1.03 mGy) and ED (1.6 ± 0.4 mSv) were slightly higher in females, these differences were not statistically significant compared to males (mean thyroid dose, 2.52 ± 1.31 mGy; mean ED, 1.5 ± 0.4 mSv). Conversely, there was a significant difference between the mean thyroid LAR of females (0.91 ± 1.35) and males (0.20136 ± 0.29) (P = 0.001). However, the influencing parameters were virtually identical for both groups.

Conclusions

The study's results indicate that females have a higher LAR than males, which can be attributed to higher radiation sensitivity of the thyroid in females. Thus, additional care in the choice of scan parameters and irradiated scan field for female patients is recommended.

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估算和比较常规头部计算机断层扫描中男性和女性的有效剂量和终生甲状腺癌归因风险：一项多中心研究。

简介每年都要进行大量的头部计算机断层扫描（CT）。然而，由于甲状腺与辐射场非常接近，这一过程会使甲状腺暴露于电离辐射中。因此，本研究旨在估算成人头部 CT 扫描的器官剂量、有效剂量 (ED) 和甲状腺癌终生归因风险 (LAR)。收集了年龄、性别和扫描参数，包括扫描长度、管电流-时间乘积（mAs）、间距、CT 剂量指数和剂量-长度乘积（DLP）。使用 CT-Expo 软件根据扫描参数计算每位患者的甲状腺剂量和 ED。随后采用电离辐射的生物效应（BEIR）第七阶段报告中介绍的方法计算LAR：尽管女性的平均甲状腺器官剂量（2.66 ± 1.03 mGy）和ED（1.6 ± 0.4 mSv）略高于男性，但与男性（平均甲状腺剂量，2.52 ± 1.31 mGy；平均ED，1.5 ± 0.4 mSv）相比，这些差异并无统计学意义。相反，女性的平均甲状腺 LAR（0.91 ± 1.35）与男性（0.20136 ± 0.29）之间存在显著差异（P = 0.001）。然而，两组的影响参数几乎相同：研究结果表明，女性的 LAR 值高于男性，这可能是因为女性甲状腺的辐射敏感性更高。因此，建议女性患者在选择扫描参数和照射扫描野时多加注意。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Radiation Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

3.20

自引率

4.80%

发文量

审稿时长

8 weeks

期刊介绍： Journal of Medical Radiation Sciences (JMRS) is an international and multidisciplinary peer-reviewed journal that accepts manuscripts related to medical imaging / diagnostic radiography, radiation therapy, nuclear medicine, medical ultrasound / sonography, and the complementary disciplines of medical physics, radiology, radiation oncology, nursing, psychology and sociology. Manuscripts may take the form of: original articles, review articles, commentary articles, technical evaluations, case series and case studies. JMRS promotes excellence in international medical radiation science by the publication of contemporary and advanced research that encourages the adoption of the best clinical, scientific and educational practices in international communities. JMRS is the official professional journal of the Australian Society of Medical Imaging and Radiation Therapy (ASMIRT) and the New Zealand Institute of Medical Radiation Technology (NZIMRT).