Functional and structural significance of the inner-arm-dynein subspecies d in ciliary motility

IF 2.4 4区生物学 Q4 CELL BIOLOGY

Cytoskeleton Pub Date : 2024-01-12 DOI:10.1002/cm.21828

Ryosuke Yamamoto, Takahide Kon

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Abstract

Motile cilia play various important physiological roles in eukaryotic organisms including cell motility and fertility. Inside motile cilia, large motor-protein complexes called “ciliary dyneins” coordinate their activities and drive ciliary motility. The ciliary dyneins include the outer-arm dyneins, the double-headed inner-arm dynein (IDA f/I1), and several single-headed inner-arm dyneins (IDAs a, b, c, d, e, and g). Among these single-headed IDAs, one of the ciliary dyneins, IDA d, is of particular interest because of its unique properties and subunit composition. In addition, defects in this subspecies have recently been associated with several types of ciliopathies in humans, such as primary ciliary dyskinesia and multiple morphologic abnormalities of the flagellum. In this mini-review, we discuss the composition, structure, and motor properties of IDA d, which have been studied in the model organism Chlamydomonas reinhardtii, and further discuss the relationship between IDA d and human ciliopathies. In addition, we provide future perspectives and discuss remaining questions regarding this intriguing dynein subspecies.

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内臂-染料蛋白亚种 d 在睫状肌运动中的功能和结构意义。

运动纤毛在真核生物体内发挥着各种重要的生理作用，包括细胞运动和生育。在运动纤毛内部，被称为 "纤毛动力蛋白 "的大型运动蛋白复合物协调它们的活动，驱动纤毛运动。纤毛动力蛋白包括外臂动力蛋白、双头内臂动力蛋白（IDA f/I1）和几种单头内臂动力蛋白（IDAs a、b、c、d、e 和 g）。在这些单头内臂动力蛋白中，纤毛动力蛋白之一的内臂动力蛋白（IDA d）因其独特的性质和亚基组成而特别引人关注。此外，该亚种的缺陷最近还与人类的几种纤毛疾病相关，如原发性纤毛运动障碍和鞭毛的多种形态异常。在这篇微型综述中，我们讨论了在模式生物莱茵衣藻中研究的 IDA d 的组成、结构和运动特性，并进一步讨论了 IDA d 与人类纤毛疾病之间的关系。此外，我们还提供了未来的展望，并讨论了有关这一有趣的动力蛋白亚种的其余问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytoskeleton CELL BIOLOGY-

CiteScore

5.50

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Cytoskeleton focuses on all aspects of cytoskeletal research in healthy and diseased states, spanning genetic and cell biological observations, biochemical, biophysical and structural studies, mathematical modeling and theory. This includes, but is certainly not limited to, classic polymer systems of eukaryotic cells and their structural sites of attachment on membranes and organelles, as well as the bacterial cytoskeleton, the nucleoskeleton, and uncoventional polymer systems with structural/organizational roles. Cytoskeleton is published in 12 issues annually, and special issues will be dedicated to especially-active or newly-emerging areas of cytoskeletal research.