Insights from in vivo preclinical cancer studies with histotripsy.

IF 3 3区 医学 Q2 ONCOLOGY
International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-01-12 DOI:10.1080/02656736.2023.2297650
Tejaswi Worlikar, Timothy Hall, Man Zhang, Mishal Mendiratta-Lala, Michael Green, Clifford S Cho, Zhen Xu
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引用次数: 0

Abstract

Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technique that mechanically fractionates target tissue into acellular homogenate via controlled acoustic cavitation. Histotripsy has been evaluated for various preclinical applications requiring noninvasive tissue removal including cancer, brain surgery, blood clot and hematoma liquefaction, and correction of neonatal congenital heart defects. Promising preclinical results including local tumor suppression, improved survival outcomes, local and systemic anti-tumor immune responses, and histotripsy-induced abscopal effects have been reported in various animal tumor models. Histotripsy is also being investigated in veterinary patients with spontaneously arising tumors. Research is underway to combine histotripsy with immunotherapy and chemotherapy to improve therapeutic outcomes. In addition to preclinical cancer research, human clinical trials are ongoing for the treatment of liver tumors and renal tumors. Histotripsy has been recently approved by the FDA for noninvasive treatment of liver tumors. This review highlights key learnings from in vivo shock-scattering histotripsy, intrinsic threshold histotripsy, and boiling histotripsy cancer studies treating cancers of different anatomic locations and discusses the major considerations in planning in vivo histotripsy studies regarding instrumentation, tumor model, study design, treatment dose, and post-treatment tumor monitoring.

利用组旋技术进行活体临床前癌症研究的启示
组织切削术是第一种非侵入性、非电离、非热消融技术,它通过受控声空化作用将目标组织机械地分割成无细胞匀浆。组织切削术已被评估用于各种需要无创组织切除的临床前应用,包括癌症、脑外科手术、血凝块和血肿液化以及新生儿先天性心脏缺陷矫正。据报道,在各种动物肿瘤模型中,临床前研究取得了可喜的成果,包括局部肿瘤抑制、生存率提高、局部和全身抗肿瘤免疫反应以及组织胞浆诱导的脱落效应。目前还在对患有自发性肿瘤的兽医患者进行组织切碎术研究。目前正在研究如何将组织细胞震荡疗法与免疫疗法和化疗相结合,以提高治疗效果。除了临床前癌症研究外,治疗肝脏肿瘤和肾脏肿瘤的人体临床试验也在进行中。最近,美国食品及药物管理局已批准组织切片疗法用于肝脏肿瘤的无创治疗。本综述重点介绍了治疗不同解剖位置癌症的体内冲击散射组织切碎术、固有阈值组织切碎术和沸腾组织切碎术癌症研究的主要经验,并讨论了计划体内组织切碎术研究时在仪器、肿瘤模型、研究设计、治疗剂量和治疗后肿瘤监测方面的主要注意事项。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
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