Neural oscillations underlying the neural gating of respiratory sensations in generalized anxiety disorder

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-09 DOI:10.1016/j.resp.2024.104215

Kai-Jie Liang , Chia-Hsiung Cheng , Chia-Yih Liu , Shih-Chieh Hsu , Andreas von Leupoldt , Valentina Jelinčić , Pei-Ying S. Chan

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Abstract

Individuals with generalized anxiety disorder (GAD) have been shown to have altered neural gating of respiratory sensations (NGRS) using respiratory-related evoked potentials (RREP); however, corresponding neural oscillatory activities remain unexplored. The present study aimed to investigate altered NGRS in individuals with GAD using both time and time-frequency analysis. Nineteen individuals with GAD and 28 healthy controls were recruited. Paired inspiratory occlusions were delivered to elicit cortical neural activations measured from electroencephalography. The GAD group showed smaller N1 amplitudes to the first stimulus (S1), lower evoked gamma and larger evoked beta oscillations compared to controls. Both groups showed larger N1, P3, beta power and theta power in response to S1 compared to S2, suggesting a neural gating phenomenon. These findings suggest that N1, gamma and beta frequency oscillations may be indicators for altered respiratory sensation in GAD populations and that the N1, P3, beta and theta oscillations can reflect the neural gating of respiratory sensations.

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广泛性焦虑症患者呼吸感觉神经门控的基础神经振荡

利用呼吸相关诱发电位（RREP）研究表明，广泛性焦虑症（GAD）患者的呼吸感觉神经门控（NGRS）发生了改变；然而，相应的神经振荡活动仍未得到研究。本研究旨在使用时间和时间频率分析法研究 GAD 患者的 NGRS 变化。研究人员招募了 19 名 GAD 患者和 28 名健康对照者。通过脑电图测量成对吸气闭塞引起皮层神经激活。与对照组相比，GAD 组对第一个刺激（S1）表现出较小的 N1 振幅、较低的诱发伽马振荡和较大的诱发贝塔振荡。与 S2 相比，两组患者对 S1 的 N1、P3、β 功率和 Theta 功率都较大，这表明存在神经门控现象。这些研究结果表明，N1、γ和β频率振荡可能是GAD人群呼吸感觉改变的指标，N1、P3、β和θ振荡可反映呼吸感觉的神经门控。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.