Zeynep Öztürk, O Alphan Küpesiz, Gülsün Karasu, Vedat Uygun, Nihal Oygür, M Akif Yeşilipek
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引用次数: 0
Abstract
Background: In a screening study conducted on adults, the prevalence of sickle cell traits in Antalya was found to be 0.24%. Since no screening studies have been conducted in the neonatal period in our region, the exact incidence has not been determined. In this study, we aim to report our experience of neonatal screening for sickle cell disease in Antalya, Türkiye.
Methods: During a 14-month period, 2562 heel prick blood samples, taken on filter paper from Akdeniz University Hospital, Antalya Education and Research Hospital and Antalya Atatürk State Hospital and four other healthcare centers, were studied using the high pressure liquid chromatography method. Blood samples were studied using the `Sickle Cell Short Program` test method on a Bio Rad Variant device.
Results: In the study, no patients with sickle cell disease were identified. Four newborns who were sickle cell carriers (0.15%) and two newborns who were Hemoglobin D carriers (0.08 %), were found.
Conclusion: Considering the efficiency and cost calculations made as a result of the data obtained from our study, it was concluded that sickle cell screening would not be effective in newborns. It seems more effective and economical to screen the children of parents, who are found to be at risk for Hemoglobin S carriage as a result of premarital tests.
背景:在一项针对成年人的筛查研究中,发现安塔利亚地区镰状细胞性状的发病率为 0.24%。由于本地区尚未开展新生儿期筛查研究,因此尚未确定确切的发病率。在本研究中,我们旨在报告土耳其安塔利亚地区新生儿镰状细胞病筛查的经验:在为期 14 个月的时间里,我们使用高压液相色谱法对来自阿克登尼兹大学医院、安塔利亚教育与研究医院、安塔利亚阿塔图尔克国立医院和其他四家医疗中心的 2562 份用滤纸采集的足跟刺血样本进行了研究。使用 Bio Rad Variant 设备上的 "镰状细胞简易程序 "测试方法对血液样本进行了研究:研究中未发现镰状细胞病患者。结果:研究中未发现镰状细胞病患者,但发现 4 名新生儿为镰状细胞携带者(0.15%),2 名新生儿为血红蛋白 D 携带者(0.08%):根据我们的研究数据进行效率和成本计算后得出结论,新生儿镰状细胞筛查并不有效。如果父母在婚前检查中发现子女有携带 S 型血红蛋白的风险,那么对他们的子女进行筛查似乎更为有效和经济。