Novel Products as Promising Therapeutic Agents for Angiogenesis Inhibition.

Current drug delivery Pub Date : 2024-01-09 DOI:10.2174/0115672018277869231217165048

Shaheen Sultana, Shahnaz Sultana, Shehla Nasar Mir Najib Ullah, Ameeduzzafar Zafar

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Abstract

Objective: Angiogenesis is the process of forming new blood vessels from pre-existing vessels and occurs during development, wound healing, and tumor growth. In this review, we aimed to present a comprehensive view of various factors contributing to angiogenesis during carcinogenesis. Anti-angiogenesis agents prevent or slow down cancer growth by interrupting the nutrients and blood supply to the tumor cells, and thus can prove beneficial for treatment.

Method: The discovery of several novel angiogenic inhibitors has helped to reduce both morbidity and mortality from several life-threatening diseases, such as carcinomas. There is an urgent need for a new comprehensive treatment strategy combining novel anti-angiogenic agents for the control of cancer. The article contains details of various angiogenic inhibitors that have been adopted by scientists to formulate and optimize such systems in order to make them suitable for cancer.

Results: The results of several researches have been summarized in the article and all of the data support the claim that anti-angiogenic agent is beneficial for cancer treatment.

Conclusion: This review focuses on novel antiangiogenic agents that play a crucial role in controlling carcinogenesis.

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抑制血管生成的新型治疗药物。

目的：血管生成是由原有血管形成新血管的过程，发生在发育、伤口愈合和肿瘤生长过程中。在这篇综述中，我们旨在全面介绍癌变过程中导致血管生成的各种因素。抗血管生成药物通过阻断肿瘤细胞的营养和血液供应，防止或减缓癌症的生长，从而有利于治疗：方法：几种新型血管生成抑制剂的发现有助于降低几种危及生命的疾病（如癌症）的发病率和死亡率。目前迫切需要一种新的综合治疗策略，将新型抗血管生成药物结合起来，以控制癌症。本文详细介绍了科学家们采用的各种血管生成抑制剂，以配制和优化此类系统，使其适用于癌症：结果：文章总结了多项研究成果，所有数据都支持抗血管生成剂有利于癌症治疗的说法：本综述重点介绍了在控制癌变方面发挥关键作用的新型抗血管生成剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Current drug delivery

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