Iron and Vitamin B12 Deficiency in Patients with Autoimmune Gastritis and Helicobacter pylori Gastritis: Results from a Prospective Multicenter Study.

IF 2 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Digestive Diseases Pub Date : 2024-01-01 Epub Date: 2024-01-10 DOI:10.1159/000535206

Malgorzata Osmola, Nicolas Chapelle, Marie-Anne Vibet, Edith Bigot-Corbel, Damien Masson, Caroline Hemont, Adam Jirka, Justine Blin, David Tougeron, Driffa Moussata, Dominique Lamarque, Regis Josien, Jean-François Mosnier, Jérôme Martin, Tamara Matysiak-Budnik

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引用次数: 0

Abstract

Introduction: Iron and vitamin B12 deficiencies are common in patients with atrophic gastritis, but there are limited data on the prevalence of these deficiencies in different types of atrophic gastritis.

Methods: This multicenter, prospective study assessed micronutrient concentrations in histologically confirmed autoimmune gastritis (AIG, n = 45), Helicobacter pylori-related non-autoimmune gastritis (NAIG, n = 109), and control patients (n = 201). A multivariate analysis was performed to determine factors influencing those deficiencies.

Results: The median vitamin B12 concentration was significantly lower in AIG (367.5 pg/mL, Q1, Q3: 235.5, 524.5) than in NAIG (445.0 pg/mL, Q1, Q3: 355.0, 565.0, p = 0.001) and control patients (391.0 pg/mL, Q1, Q3: 323.5, 488.7, p = 0.001). Vitamin B12 deficiency was found in 13.3%, 1.5%, and 2.8% of AIG, NAIG, and control patients, respectively. Similarly, the median ferritin concentration was significantly lower in AIG (39.5 ng/mL, Q1, Q3: 15.4, 98.3 ng/mL) than in NAIG (80.5 ng/mL, Q1, Q3: 43.6, 133.9, p = 0.04) and control patients (66.5 ng/mL, Q1, Q3: 33.4, 119.8, p = 0.007). Iron deficiency and iron deficiency adjusted to CRP were present in 28.9% and 33.3% of AIG, 12.8% and 16.5% of NAIG, and 12.9% and 18.4% of controls, respectively. Multivariate analysis demonstrated that AIG patients had a higher risk of developing vitamin B12 deficiency (OR: 11.52 [2.85-57.64, p = 0.001]) and iron deficiency (OR: 2.92 [1.32-6.30, p = 0.007]) compared to control patients. Factors like age, sex, and H. pylori status did not affect the occurrence of vitamin B12 or iron deficiency.

Conclusion: Iron and vitamin B12 deficiencies are more commonly observed in patients with AIG than in those with NAIG or control patients. Therefore, it is essential to screen for both iron and vitamin B12 deficiencies in AIG patients and include the treatment of micronutrient deficiencies in the management of atrophic gastritis patients.

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自身免疫性胃炎和幽门螺旋杆菌胃炎患者的铁和维生素 B12 缺乏症：一项前瞻性多中心研究的结果。

引言萎缩性胃炎患者普遍缺乏铁和维生素 B12，但关于不同类型萎缩性胃炎患者缺乏这些营养素的数据却很有限。方法这项多中心前瞻性研究评估了经组织学证实的自身免疫性胃炎（AIG，45 人）、幽门螺杆菌相关的非自身免疫性胃炎（NAIG，109 人）患者和对照组（201 人）的微量营养素浓度。为确定影响这些缺乏症的因素，进行了多变量分析。结果 AIG 患者维生素 B12 浓度的中位数（367.5 pg/mL）明显低于 NAIG 患者（445.0 pg/mL，P=0.001）和对照组患者（391.0 pg/mL，P=0.001）。在 AIG、NAIG 和对照组中，分别有 13.3%、1.5% 和 2.8% 的人缺乏维生素 B12。AIG 的铁蛋白浓度中位数（39.5 纳克/毫升）明显低于 NAIG（80.5 纳克/毫升，133.9，p=0.04）和对照组（66.5 纳克/毫升，p=0.007）。分别有 28.9% 和 33.3% 的 AIG、12.8% 和 16.5% 的 NAIG 以及 12.9% 和 18.4% 的对照组存在铁缺乏症和根据 CRP 调整的铁缺乏症。多变量分析表明，与对照组相比，AIG 患维生素 B12 缺乏症（OR 11.52 (2.85-57.64, p=0.001)）和铁缺乏症（OR 2.92 (1.32- 6.30, p=0.007)）的风险更高。年龄、性别和幽门螺杆菌状态对维生素 B12 或铁缺乏症没有影响。结论与 NAIG 或对照组相比，铁和维生素 B12 缺乏症在 AIG 患者中更为常见。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Digestive Diseases 医学-胃肠肝病学

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Each issue of this journal is dedicated to a special topic of current interest, covering both clinical and basic science topics in gastrointestinal function and disorders. The contents of each issue are comprehensive and reflect the state of the art, featuring editorials, reviews, mini reviews and original papers. These individual contributions encompass a variety of disciplines including all fields of gastroenterology. ''Digestive Diseases'' bridges the communication gap between advances made in the academic setting and their application in patient care. The journal is a valuable service for clinicians, specialists and physicians-in-training.