Identification of genomic regions associated with resistance to gastrointestinal parasites in an indigenous sheep by single- and multiple-locus methods

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-10 DOI:10.1111/age.13392

S. A. Rafat, M. Barbato, R. Hajializadeh Valilou, G. H. Moghaddam, A. Nematollahi, K. Periasamy, R. Pichler, P. Ajmone Marsan

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Abstract

We investigated the association between 157 SNPs located in 75 candidate genes involved in the immune system and proxy traits for resistance to gastrointestinal nematodes in sheep. A total of 211 lambs from eight flocks were sampled. Nematode eggs per gram were counted and classified as: (i) Strongyles, (ii) Nematodirus spp., (iii) Trichuris spp. and (iv) Marshallagia marshalli. Single- and multiple-locus models were used to test the marker–trait associations. Seven significant SNPs were identified on chromosomes OAR6, 15, 16, and 19. These findings provide insights for breeding nemarode-resistant traits in low-input production systems. General linear model, fixed and random model circulating probability unification, and Bayesian-information and linkage-disequilibrium iteratively nested keyway analyses identified a significant association between the eggs per gram of Strongyles nematodes and a specific variant of the PRLR gene.

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通过单病灶和多病灶方法鉴定与一种土著绵羊对胃肠道寄生虫的抵抗力有关的基因组区域。

我们研究了位于涉及免疫系统的 75 个候选基因中的 157 个 SNPs 与绵羊胃肠道线虫抗性替代性状之间的关联。我们对来自 8 个羊群的 211 只羔羊进行了采样。对每克羔羊体内的线虫卵进行计数并分类：(i) 线虫；(ii) Nematodirus spp.；(iii) Trichuris spp.；(iv) Marshallagia marshalli。采用单病灶和多病灶模型检验标记与性状的关联。在 OAR6、15、16 和 19 号染色体上发现了七个重要的 SNPs。这些发现为在低投入生产系统中培育抗线虫性状提供了启示。通过一般线性模型、固定和随机模型循环概率统一以及贝叶斯信息和连锁失衡迭代嵌套键槽分析，确定了每克斯特龙线虫的虫卵数与 PRLR 基因的一个特定变异之间存在显著关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.