Dive into the details of radionuclide antibody conjugates: what role do EPR effects and LETs of different radionuclides play?

IF 2 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
American journal of nuclear medicine and molecular imaging Pub Date : 2023-12-25 eCollection Date: 2023-01-01
Sixuan Cheng, Dawei Jiang, Mengting Li
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引用次数: 0

Abstract

Radionuclide antibody conjugate (RAC) is a promising diagnostic and therapeutic tool. It combines radionuclides and antibodies by connecting arms and chelating agents, offering precise targeting and potent killing of tumor cells. However, further development and optimization of this radiopharmaceutical is needed to enhance the ultimate substantive efficacy for clinical translation. In this issue of AJNMMI, Strand et al. evaluated the enhanced permeability effect and different linear energy transfer (LET) of radionuclides in a prostate cancer xenograft model. The results showed that specific targeting might negatively influence normal organ uptake when targeting secreted antigens and different LETs of radionuclides might have diverse effects on receptor expression and cell proliferation in tumors. The findings provide new thinking for the development of antibody-based radiopharmaceuticals.

深入了解放射性核素抗体共轭物的细节:不同放射性核素的 EPR 效应和 LET 起什么作用?
放射性核素抗体共轭物(RAC)是一种前景广阔的诊断和治疗工具。它通过连接臂和螯合剂将放射性核素和抗体结合在一起,对肿瘤细胞具有精确靶向和强效杀伤作用。然而,这种放射性药物还需要进一步开发和优化,以提高最终的实质性疗效,实现临床转化。在本期 AJNMMI 杂志上,Strand 等人评估了放射性核素在前列腺癌异种移植模型中的增强渗透效应和不同的线性能量转移 (LET)。结果表明,当靶向分泌型抗原时,特异性靶向可能会对正常器官的吸收产生负面影响,而不同线性能量转移(LET)的放射性核素可能会对肿瘤中的受体表达和细胞增殖产生不同的影响。这些发现为开发基于抗体的放射性药物提供了新思路。
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来源期刊
American journal of nuclear medicine and molecular imaging
American journal of nuclear medicine and molecular imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
自引率
4.00%
发文量
4
期刊介绍: The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.
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