Neuroimmunology and ageing – the state of the art

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Moisés E. Bauer, Graham Pawelec, Roberto Paganelli
{"title":"Neuroimmunology and ageing – the state of the art","authors":"Moisés E. Bauer, Graham Pawelec, Roberto Paganelli","doi":"10.1186/s12979-024-00411-w","DOIUrl":null,"url":null,"abstract":"<p>For decades, the central nervous system (CNS) was known as an immune-privileged site. This concept was formulated based on experimental studies that demonstrated that, unlike what was observed in peripheral organs, skin grafts were not rejected when transplanted into the brain parenchyma. The presence of the blood-brain barrier (BBB), capable of selectively regulating the entry of molecules and cells from the bloodstream into the brain parenchyma, and the absence of conventional lymphatic vessels contributed to reinforcing this concept [1]. However, meningeal lymphatic vessels in the dura mater and, more recently, glymphatic vessels have raised questions about the dogma of the CNS as an immune-privileged site [2, 3]. The CNS has thus adopted mechanisms that enable communication with the immune system, which is crucial for a healthy brain.</p><p>Recent studies highlight the borders of the CNS as pivotal sites of neuro-immune interactions. Under physiological conditions, characterized by the absence of leukocytes in the brain parenchyma, innate immune cells, such as macrophages, and adaptive immune cells, such as T and B cells, are present in meningeal regions, in the choroid plexus and perivascular spaces. In addition to actively participating in immune surveillance in the CNS, these cells contribute to the maintenance of brain homeostasis and may influence behavioural and cognitive responses [4, 5]. For instance, cytokines secreted by immune cells, localized at the brain borders, may change behaviour through modulation of neuronal activities in distinct brain regions [5]. Indeed, several T cell-related cytokines have been shown to modulate complex CNS functions, by inducing changes in neuronal physiology: interferon γ (IFN-γ) alters sociability [6], IL-17 maintains anxiety and spatial learning [7], and IL-4 regulates learning and memory [8].</p><p>Inflammaging is a low level pro-inflammatory state which is believed to be a major contributor to biological aging which underlies many age-associated diseases. Peripheral inflammation significantly affects brain function and contributes to the development of several neurological disorders. Changes in interactions between the CNS and the immune system, such as those observed during ageing, could predispose to the development of neurodegenerative and neuropsychiatric diseases. Both ageing and neuropsychiatric disorders of older adults seem to converge on the pathogenetic role of inflammation, hence the notion of neuroinflammation. Increasing evidence indicates the role of neuroinflammation in age-related neurodegenerative diseases, such as Alzheimer’s Disease (AD) and Parkinson’s disease (PD). The neuropathological features of these diseases include aggregation and accumulation of intracellular and/or extracellular proteins that are associated with neuronal loss in specific regions of the brain. Furthermore, proliferation and activation of glial cells (i.e., “gliosis”) are well established in these diseases. In this context, neuroinflammation is essentially characterized by the activation of microglia and innate inflammatory pathways, such as activation of the NLRP3 inflammasome, increased expression of transcription factors for genes encoding inflammatory proteins (e.g., nuclear transcription factor κ-B, NF-κB), increased secretion of pro-inflammatory cytokines and chemokines, and increased production of reactive oxygen species (ROS) [9]. In addition, the phagocytic clearance of protein aggregates and cellular debris by microglia deteriorates during ageing and degenerative disorders [10]. Indeed, much of the literature points to an important role of tissue phagocytic cells in the pathogenesis of AD. On the other hand, peripheral immune cells, such as lymphocytes, may have modulatory functions, but the contribution of these cells to the pathogenesis of neurodegenerative diseases is still debatable [11]. Recent additions to this scenario have been published with the transcriptomic atlas of different regions of the brain [12].</p><p>This Topical Collection of papers on Neuroimmunology and Ageing showcases a growing body of work characterizing the complex crosstalk of brain and immune cells (CNS-resident or circulating) during healthy ageing as well as characterizing the neuroinflammation observed in neurodegenerative diseases and neuropsychiatric disorders.</p><h3>Neuroimmune changes during healthy brain ageing: impact of sex and lifestyle</h3><p>As the brain ages, the immune cells at peripheral sites as well as in the CNS change significantly – and T cells from outside the brain may infiltrate the brain tissue. The reasons for this age-related trafficking of T cells into the brain are not well understood. Several papers in this Topical Collection contribute to clarifying this issue. Analysing the transcriptional profiles of individual cells from young and old mice, ZHANG et al. (2022) constructed interaction networks between brain endothelial cells (BECs), microglia and T cells (https://immunityageing.biomedcentral.com/articles/; https://doi.org/10.1186/s12979-022-00289-6). T-cell infiltration was observed in the subventricular zone of aged mice. Cell–cell interaction analysis revealed that aged microglia released CCL3 to recruit peripheral CD8 + memory T cells. As a potential consequence, the aged microglia changed their phenotype towards a pro-inflammatory state, releasing TNF-α to upregulate the expression of VCAM1 and ICAM1 in BEC - therefore promoting the migration of peripheral T cells into the brain. In vitro, experiments revealed that human microglia would also transit to a chemotactic phenotype when treated with CSF from elderly subjects. This study reveals the neuroimmune pathways involved in maintaining brain homeostasis during normal ageing. A unique map of immune cells in the “normal” CNS is a useful guide to assess the changes observed in disease. This was provided by NEVALAINEN et al. (2022) in a study of 22 cell types, representative of natural and adaptive immune cells, identified in 13 different brain regions of 55 donors without diseases affecting the brain. The proportion of immune cells was determined by assessing multiple gene signatures and analyzed by the cytometry tool CIBERSORTx, thus establishing the cell subtypes using levels of expression of 547 signature genes (https://doi.org/10.1186/s12979-022-00302-y). The effect of aging was to increase the presence of innate immune cells (mainly monocytes) and decrease all adaptive immune cells in distinctive brain regions. The age-associated differences in the composition of infiltrating immune cells are consistent with a role in tissue homeostasis.</p><p>Women with major depression tend to experience more cognitive problems than men. This sex-related cognitive bias includes negative thinking patterns that affect how people remember and interpret information. The cognitive bias is influenced by neurogenesis in the hippocampus and by neuroinflammation. Given the association of cognitive bias to neurogenesis and inflammation, HODGES et al. (2022) examined associations between cognitive bias, neurogenesis in the hippocampus, and cytokine levels in the ventral hippocampus (HPC) and basolateral amygdala (BLA) of male and female rats across the lifespan (https://immunityageing.biomedcentral.com/articles/; https://doi.org/10.1186/s12979-022-00299-4). Following testing for cognitive bias, male rats had more inflammatory cytokines in the ventral HPC than females in adolescence. In young adulthood, female rats had more IFN-γ, IL-1β, IL-4, IL-5, and IL-10 in the BLA than males. Middle-aged rats had more IL-13, TNF-α, and CXCL1 in both regions than younger groups. Adolescent male rats had higher hippocampal neurogenesis than adolescent females after cognitive bias testing. Neurogenesis in the dorsal HPC was negatively associated with negative cognitive bias in young adult males. Taken together, these results document that the association between negative cognitive bias, hippocampal neurogenesis, and inflammation in the brain differs by age and sex.</p><p>Age-related changes in lifestyle (for example, those impacting body composition) may also be associated with neuroinflammation and increased morbidity risk. Obesity rates are rising significantly around the world. Obesity leads to many complications, such as increasing the risk of cognitive decline in older age. Several changes in the immune system, such as inflammageing and immunosenescence, are common in both obesity and ageing and may affect cognitive decline. Therefore, immune system changes across the lifespan may influence how obesity affects neuroinflammation and cognitive decline related to it. To better understand this relationship, HENN et al. (2022) investigated the metabolic and inflammatory profiles associated with cognitive changes using a mouse model of obesity with a high-fat diet (HFD) (https://immunityageing.biomedcentral.com/articles/; https://doi.org/10.1186/s12979-022-00323-7). Mice on an HFD had significant age-related changes in hippocampal gene expression. The HFD caused a dysmetabolic phenotype in both young and middle-aged groups. However, older age exacerbated HFD cognitive and neuroinflammatory changes, with altered expression of hippocampal inflammatory genes. Taken together, these data indicate that obesity (HFD) promotes a premature ageing phenotype in the brain, which is indicative of inflammageing and immunosenescence. The pro- or anti-inflammatory effects of diet on cognitive impairment were assessed by LIU et al. (2023) in a cohort of 2944 people followed for 2 years; the longitudinal study showed increased decline in males with a higher dietary inflammatory index. This was further confirmed by a nested case-control study. The relationship also held with systemic inflammatory indexes derived from leukocyte counts, in agreement with an array of inflammatory cytokines, and it was mediated by one of them (SIRI) which acted upon leukocyte telomere length as well as mitochondrial DNA copy number, which were also independently associated with mild cognitive impairment (https://doi.org/10.1186/s12979-022-00326-4).</p><h3>Neuroimmune changes associated with neuropsychiatric disorders</h3><p>Neuropsychiatric disorders, including major depression and bipolar disorder, have been associated with several characteristics of premature ageing, such as chronic low-grade inflammation (inflammageing), cells with shortened telomeres and dysregulated immune responses [13]. These changes may impact disease progression (ex., promoting neuroinflammation) as well as immunity to infections and vaccines. Here, FORD and SAVITZ (2022) review recent data suggesting that depression is a risk factor for both adverse outcomes following COVID-19 infection and for reduced COVID-19 vaccine immunogenicity (https://immunityageing.biomedcentral.com/articles/; https://doi.org/10.1186/s12979-022-00288-7).</p><p>In an epidemiological study of very old Chinese adults in Hainan, SUN et al. (2022) found that depressive symptoms, assessed according to the Geriatric Depression Scale, were present in women of more advanced age (99 yrs average), and were associated with higher IgA serum levels, together with smaller but significant decreases in haemoglobin, IgM and C3 levels (https://doi.org/10.1186/s12979-022-00283-y). This finding deserves further scrutiny for a mechanistic explanation.</p><h3>Neuroinflammation in the pathogenesis of neurodegenerative diseases</h3><p>Neuroinflammation is also key to the pathogenesis of neurodegenerative diseases [10]. Natural antibodies (nAbs) against aggregation-prone proteins have been found in both healthy subjects as well as in patients with neurodegenerative disorders. Here, PAGANELLI et al. (2023) measured nAbs to Aβ protein in a group of Italian patients with Alzheimer’s Disease (AD), vascular dementia, non-demented patients with Parkinson’s Disease (PD) and healthy elderly controls (https://immunityageing.biomedcentral.com/articles/https://doi.org/10.1186/s12979-023-00336-w). The Aβ antibody levels in AD were similar to age- and sex-matched controls, but significantly reduced in PD. This study may identify patients that could be more prone to amyloid aggregation.</p><p>Peripheral evidence of inflammatory processes may shed light on localized neuroinflammation, as COSTANTINI et al. (2023) propose in their paper on different gene expression of acetylcholine receptor (AChR) subunits in blood mononuclear cells (https://doi.org/10.1186/s12979-023-00329-9). Some types were underrepresented in leukocytes from patients with Lewy body-type dementia and Alzheimer disease, but with different patterns, as also the case for inflammatory cytokines which were more highly expressed but at different levels and without association with AChRs – despite reports that AChR7 and AChR2/4 suppress the release of proinflammatory cytokines when activated.</p><p>The blood-brain interaction was also investigated by LI et al. (2023) in mice transgenic for APP/PS1, and in a parabiotic model with wild-type mice. They studied the effects of high levels of amyloid Aβ on circulating macrophages (https://doi.org/10.1186/s12979-023-00366-4) and found that high plasma levels of Aβ1–42 play a biphasic role, i.e. inhibiting effects on peripheral pro-inflammatory macrophages in the early stage of the model, but promoting inflammation in the late stage. The effects are suggested to be mediated by myeloid-derived suppressor cells in the spleen and myeloid precursors in the bone marrow, adding more layers of complexity.</p><p>Signatures of pain arising from nerve injuries are generally associated with changes in cell numbers, trafficking, and immune phenotypes within dorsal root ganglia (DRG). In this context, CHOCONTA et al. (2023) investigated neuroimmune processes involved in the DRG of Fabry disease (https://immunityageing.biomedcentral.com/articles/https://doi.org/10.1186/s12979-023-00346-8). Pain in Fabry disease (FD) is generally accepted to result from neuronal damage in the peripheral nervous system because of excess lipid storage caused by alpha-galactosidase A (α-Gal A) deficiency. Using a mouse model of FD, they report significant alterations of lysosomal signatures in sensory neurons and of macrophage morphology and phenotypes in the DRG. The changes in macrophage morphology are suggestive of premature ageing, and these cells could be targeted in better therapies.</p><h3>Interventions to mitigate age-related neuroinflammation</h3><p>This Topical Collection includes articles exploring the beneficial effects of interventions aimed to mitigate neuroinflammation. GONG et al. (2023) investigated the molecular mechanisms by which glycyrrhizic acid (GA), a saponin compound often used as a flavouring agent, improves cognition in mice through immunomodulation (https://immunityageing.biomedcentral.com/articles/https://doi.org/10.1186/s12979-023-00337-9). Single-cell sequencing data of PBMCs revealed that GA reduced age-related increases in myeloid cells and increased numbers of lymphoid lineage subpopulations. In vitro, GA significantly promoted the differentiation of hematopoietic stem cells toward lymphoid lineages, of note CD8<sup>+</sup> T cells. Moreover, GA inhibited the differentiation of CD4<sup>+</sup> T cells and myeloid (CD11b<sup>+</sup>) cells by binding to S100 calcium-binding protein 8 (S100A8) protein.</p><p>The mechanism of beneficial effects of exercise on the brain was investigated by HAN et al. (2023) by exploring the phenotypic and functional changes induced in microglia by the metabolite product of exercise, lactate. Activated microglia exhibit abnormal morphology and proliferation and release inflammatory and bioactive molecules, which may damage neurons; these investigators found that addition of lactate, through a lactate “timer”, accelerated the upregulation of homeostatic genes producing an anti-inflammatory reparative phenotype transition of microglia in mice pretreated with aluminium-D-Galactose which induces an Alzheimer-like syndrome. Induction of Arginase-1 reflected the initiation of a reparative phenotype through lactylation of histone H3 in brains of mice after exercise training, which also demonstrated improved cognitive function and less neuronal loss in the brain.</p><p>ZAMORANO et al. (2023) showed that treatment of 9-month-old male mice with the chemotherapeutic agent cisplatin causes cognitive defects that are associated with the formation of tau deposits in the hippocampus. Nasal administration of mesenchymal stromal cells (MSC) at 48 and 96 h after cisplatin prevented formation of tau deposits and normalized syndecan-2 and GFAP expression (https://doi.org/10.1186/s12979-023-00328-w). Cisplatin-induced tau cluster formation was associated with reduced executive functioning and working/spatial memory; nasal administration of MSC prevented these cognitive defects. Notably, delayed MSC administration (one month after cisplatin) also prevented tau cluster formation and cognitive alterations. Developing nasal MSC administration for treatment of accelerated brain aging and cognitive problems in cancer survivors should be feasible and would greatly improve their quality of life.</p><p>Neuroinflammation also has a key role in infection-induced neurological injury, particularly in older adults with increased incidence of sepsis following CNS infection. Brain tissue-resident memory T cells (bT<sub>RM</sub>) are recruited during CNS infection and promote pathogen control as well as deleterious inflammation. Here, CASSIDY et al. (2022) explored the anti-inflammatory actions of the microRNA miR-155 during neuroinvasive infection of mice with <i>Listeria monocytogenes</i> (https://immunityageing.biomedcentral.com/articles/; https://doi.org/10.1186/s12979-022-00281-0). Notably, anti-miR-155 treatment reduced the accumulation of brain myeloid cells in aged mice after infection, whereas CD8<sup>+</sup> bT<sub>RM</sub> were unaffected.</p><p>In a transgenic RNAi screen using Drosophila as a model, YUE et al. (2023) report that knockdown of Dsor1 (the Drosophila MAPK kinase dMEK) suppressed protein inclusion containing TAR DNA-binding protein of 43 kDa (TDP-43) toxicity, without altering TDP-43 phosphorylation or protein levels (https://doi.org/10.1186/s12979-023-00354-8). TDP-43 is an important DNA/RNA-binding protein that is associated with age-related neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal dementia. Further investigation revealed that the Dsor1 downstream gene rl (dERK) was abnormally upregulated in TDP-43 flies, and neuronal overexpression of dERK induced profound upregulation of antimicrobial peptides (AMPs). This induced immune overactivation in TDP-43 flies, which was suppressed by downregulation of the MEK/ERK pathway in TDP-43 fly neurons. Neuronal knockdown of Dnr1, a negative regulator of the Drosophila immune deficiency (IMD) pathway, activated innate immunity and boosted AMP expression independent of regulation by the MEK/ERK pathway. An FDA-approved MEK inhibitor (trametinib) markedly suppressed immune overactivation, alleviated motor deficits and prolonged the lifespan of TDP-43 flies, but did not exhibit such features in either AD or spinocerebellar ataxia type 3 (SCA3) fly models. This study sheds new light on the pathogenesis of TDP-43 neurological damage.</p><p>MÜLLER and DI BENEDETTO (2023) review neuroimmune interactions in the aged brain and highlight the impact of COVID-19 on the functional systems already modulated by immunosenescence and neuroinflammation (https://immunityageing.biomedcentral.com/articles/https://doi.org/10.1186/s12979-023-00341-z). They discuss the potential neuroimmune interactions involved in COVID-19 sequelae, reviewing mechanisms and biological factors that may contribute to persisting long COVID conditions. The main biological mechanisms involved with long COVID are discussed as well as various interventional options (e.g. nutritional, exercise and behavioural) that may mitigate the neuroimmune activation associated with unbalanced inflammatory responses.</p><p>In a comprehensive review, SAHEBNASAGH et al. (2022) describe the concept of neurohormesis and apply it to herbal remedies and plant-derived drugs used to alleviate or cure the symptoms of neurological diseases (https://doi.org/10.1186/s12979-022-00292-x). These include both neurodegenerative (Alzheimer, Parkinson) as well as other neurological disorders such as autism and Huntington’s disease. The reader is taken through neurohormetic herbal medicines (i.e. the hormetic properties of phytochemicals used to treat neurological disorders<i>)</i> for aging, neuroprotection, memory enhancement, and the effects of these phytochemicals on the immune system and the mitochondria functions.</p><p>The studies described in the 17 papers in this Topical Collection give an all-encompassing view of the complex relationships between immune system changes with ageing, and several diseases of the central nervous system, as well as novel potential targets able to influence the progression of neurological impairment.</p><p>Not applicable.</p><ol data-track-component=\"outbound reference\"><li data-counter=\"1.\"><p>Engelhardt B, Vajkoczy P, Weller RO. The movers and shapers in immune privilege of the CNS. Nat Immunol. 2017;18(2):123–31.</p><p>Article CAS PubMed Google Scholar </p></li><li data-counter=\"2.\"><p>Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, et al. 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Ann N Y Acad Sci. 2019;1437(1):57–67.</p><p>Article CAS PubMed Google Scholar </p></li></ol><p>Download references<svg aria-hidden=\"true\" focusable=\"false\" height=\"16\" role=\"img\" width=\"16\"><use xlink:href=\"#icon-eds-i-download-medium\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"></use></svg></p><p>The Authors are indebted to Ms. Britta Mueller for precious help with manuscript handling during the review process and editorial work for the Topical Collection.</p><p>No funds were made available for this publication.</p><h3>Authors and Affiliations</h3><ol><li><p>Laboratory of Immunobiology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil</p><p>Moisés E. Bauer</p></li><li><p>Department of Immunology, University of Tübingen, Tübingen, Germany</p><p>Graham Pawelec</p></li><li><p>Health Sciences North Research Institute, Sudbury, ON, Canada</p><p>Graham Pawelec</p></li><li><p>YDA-Institute of Clinical Immunotherapy and Advanced Biological Treatments, Pescara, 65121, Italy</p><p>Roberto Paganelli</p></li><li><p>Internal Medicine, UniCamillus, International Medical University in Rome, via di Sant’Alessandro 6, Rome, 00131, Italy</p><p>Roberto Paganelli</p></li></ol><span>Authors</span><ol><li><span>Moisés E. Bauer</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Graham Pawelec</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Roberto Paganelli</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li></ol><h3>Contributions</h3><p>M.E.B. and R.P. wrote the first draft of the editorial; G.P. provided further observations and corrections to the text; all co-authors revised the manuscript and approved the final version.</p><h3>Corresponding author</h3><p>Correspondence to Roberto Paganelli.</p><h3>Competing interests</h3>\n<p>The Authors M.E.B. and R.P. declare they have also served as Guest Editors for this Topical Collection, and G.A. as Editor-in-Chief for this Journal.</p><h3>Publisher’s Note</h3><p>Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p><p><b>Open Access</b> This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. 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Abstract

For decades, the central nervous system (CNS) was known as an immune-privileged site. This concept was formulated based on experimental studies that demonstrated that, unlike what was observed in peripheral organs, skin grafts were not rejected when transplanted into the brain parenchyma. The presence of the blood-brain barrier (BBB), capable of selectively regulating the entry of molecules and cells from the bloodstream into the brain parenchyma, and the absence of conventional lymphatic vessels contributed to reinforcing this concept [1]. However, meningeal lymphatic vessels in the dura mater and, more recently, glymphatic vessels have raised questions about the dogma of the CNS as an immune-privileged site [2, 3]. The CNS has thus adopted mechanisms that enable communication with the immune system, which is crucial for a healthy brain.

Recent studies highlight the borders of the CNS as pivotal sites of neuro-immune interactions. Under physiological conditions, characterized by the absence of leukocytes in the brain parenchyma, innate immune cells, such as macrophages, and adaptive immune cells, such as T and B cells, are present in meningeal regions, in the choroid plexus and perivascular spaces. In addition to actively participating in immune surveillance in the CNS, these cells contribute to the maintenance of brain homeostasis and may influence behavioural and cognitive responses [4, 5]. For instance, cytokines secreted by immune cells, localized at the brain borders, may change behaviour through modulation of neuronal activities in distinct brain regions [5]. Indeed, several T cell-related cytokines have been shown to modulate complex CNS functions, by inducing changes in neuronal physiology: interferon γ (IFN-γ) alters sociability [6], IL-17 maintains anxiety and spatial learning [7], and IL-4 regulates learning and memory [8].

Inflammaging is a low level pro-inflammatory state which is believed to be a major contributor to biological aging which underlies many age-associated diseases. Peripheral inflammation significantly affects brain function and contributes to the development of several neurological disorders. Changes in interactions between the CNS and the immune system, such as those observed during ageing, could predispose to the development of neurodegenerative and neuropsychiatric diseases. Both ageing and neuropsychiatric disorders of older adults seem to converge on the pathogenetic role of inflammation, hence the notion of neuroinflammation. Increasing evidence indicates the role of neuroinflammation in age-related neurodegenerative diseases, such as Alzheimer’s Disease (AD) and Parkinson’s disease (PD). The neuropathological features of these diseases include aggregation and accumulation of intracellular and/or extracellular proteins that are associated with neuronal loss in specific regions of the brain. Furthermore, proliferation and activation of glial cells (i.e., “gliosis”) are well established in these diseases. In this context, neuroinflammation is essentially characterized by the activation of microglia and innate inflammatory pathways, such as activation of the NLRP3 inflammasome, increased expression of transcription factors for genes encoding inflammatory proteins (e.g., nuclear transcription factor κ-B, NF-κB), increased secretion of pro-inflammatory cytokines and chemokines, and increased production of reactive oxygen species (ROS) [9]. In addition, the phagocytic clearance of protein aggregates and cellular debris by microglia deteriorates during ageing and degenerative disorders [10]. Indeed, much of the literature points to an important role of tissue phagocytic cells in the pathogenesis of AD. On the other hand, peripheral immune cells, such as lymphocytes, may have modulatory functions, but the contribution of these cells to the pathogenesis of neurodegenerative diseases is still debatable [11]. Recent additions to this scenario have been published with the transcriptomic atlas of different regions of the brain [12].

This Topical Collection of papers on Neuroimmunology and Ageing showcases a growing body of work characterizing the complex crosstalk of brain and immune cells (CNS-resident or circulating) during healthy ageing as well as characterizing the neuroinflammation observed in neurodegenerative diseases and neuropsychiatric disorders.

Neuroimmune changes during healthy brain ageing: impact of sex and lifestyle

As the brain ages, the immune cells at peripheral sites as well as in the CNS change significantly – and T cells from outside the brain may infiltrate the brain tissue. The reasons for this age-related trafficking of T cells into the brain are not well understood. Several papers in this Topical Collection contribute to clarifying this issue. Analysing the transcriptional profiles of individual cells from young and old mice, ZHANG et al. (2022) constructed interaction networks between brain endothelial cells (BECs), microglia and T cells (https://immunityageing.biomedcentral.com/articles/; https://doi.org/10.1186/s12979-022-00289-6). T-cell infiltration was observed in the subventricular zone of aged mice. Cell–cell interaction analysis revealed that aged microglia released CCL3 to recruit peripheral CD8 + memory T cells. As a potential consequence, the aged microglia changed their phenotype towards a pro-inflammatory state, releasing TNF-α to upregulate the expression of VCAM1 and ICAM1 in BEC - therefore promoting the migration of peripheral T cells into the brain. In vitro, experiments revealed that human microglia would also transit to a chemotactic phenotype when treated with CSF from elderly subjects. This study reveals the neuroimmune pathways involved in maintaining brain homeostasis during normal ageing. A unique map of immune cells in the “normal” CNS is a useful guide to assess the changes observed in disease. This was provided by NEVALAINEN et al. (2022) in a study of 22 cell types, representative of natural and adaptive immune cells, identified in 13 different brain regions of 55 donors without diseases affecting the brain. The proportion of immune cells was determined by assessing multiple gene signatures and analyzed by the cytometry tool CIBERSORTx, thus establishing the cell subtypes using levels of expression of 547 signature genes (https://doi.org/10.1186/s12979-022-00302-y). The effect of aging was to increase the presence of innate immune cells (mainly monocytes) and decrease all adaptive immune cells in distinctive brain regions. The age-associated differences in the composition of infiltrating immune cells are consistent with a role in tissue homeostasis.

Women with major depression tend to experience more cognitive problems than men. This sex-related cognitive bias includes negative thinking patterns that affect how people remember and interpret information. The cognitive bias is influenced by neurogenesis in the hippocampus and by neuroinflammation. Given the association of cognitive bias to neurogenesis and inflammation, HODGES et al. (2022) examined associations between cognitive bias, neurogenesis in the hippocampus, and cytokine levels in the ventral hippocampus (HPC) and basolateral amygdala (BLA) of male and female rats across the lifespan (https://immunityageing.biomedcentral.com/articles/; https://doi.org/10.1186/s12979-022-00299-4). Following testing for cognitive bias, male rats had more inflammatory cytokines in the ventral HPC than females in adolescence. In young adulthood, female rats had more IFN-γ, IL-1β, IL-4, IL-5, and IL-10 in the BLA than males. Middle-aged rats had more IL-13, TNF-α, and CXCL1 in both regions than younger groups. Adolescent male rats had higher hippocampal neurogenesis than adolescent females after cognitive bias testing. Neurogenesis in the dorsal HPC was negatively associated with negative cognitive bias in young adult males. Taken together, these results document that the association between negative cognitive bias, hippocampal neurogenesis, and inflammation in the brain differs by age and sex.

Age-related changes in lifestyle (for example, those impacting body composition) may also be associated with neuroinflammation and increased morbidity risk. Obesity rates are rising significantly around the world. Obesity leads to many complications, such as increasing the risk of cognitive decline in older age. Several changes in the immune system, such as inflammageing and immunosenescence, are common in both obesity and ageing and may affect cognitive decline. Therefore, immune system changes across the lifespan may influence how obesity affects neuroinflammation and cognitive decline related to it. To better understand this relationship, HENN et al. (2022) investigated the metabolic and inflammatory profiles associated with cognitive changes using a mouse model of obesity with a high-fat diet (HFD) (https://immunityageing.biomedcentral.com/articles/; https://doi.org/10.1186/s12979-022-00323-7). Mice on an HFD had significant age-related changes in hippocampal gene expression. The HFD caused a dysmetabolic phenotype in both young and middle-aged groups. However, older age exacerbated HFD cognitive and neuroinflammatory changes, with altered expression of hippocampal inflammatory genes. Taken together, these data indicate that obesity (HFD) promotes a premature ageing phenotype in the brain, which is indicative of inflammageing and immunosenescence. The pro- or anti-inflammatory effects of diet on cognitive impairment were assessed by LIU et al. (2023) in a cohort of 2944 people followed for 2 years; the longitudinal study showed increased decline in males with a higher dietary inflammatory index. This was further confirmed by a nested case-control study. The relationship also held with systemic inflammatory indexes derived from leukocyte counts, in agreement with an array of inflammatory cytokines, and it was mediated by one of them (SIRI) which acted upon leukocyte telomere length as well as mitochondrial DNA copy number, which were also independently associated with mild cognitive impairment (https://doi.org/10.1186/s12979-022-00326-4).

Neuroimmune changes associated with neuropsychiatric disorders

Neuropsychiatric disorders, including major depression and bipolar disorder, have been associated with several characteristics of premature ageing, such as chronic low-grade inflammation (inflammageing), cells with shortened telomeres and dysregulated immune responses [13]. These changes may impact disease progression (ex., promoting neuroinflammation) as well as immunity to infections and vaccines. Here, FORD and SAVITZ (2022) review recent data suggesting that depression is a risk factor for both adverse outcomes following COVID-19 infection and for reduced COVID-19 vaccine immunogenicity (https://immunityageing.biomedcentral.com/articles/; https://doi.org/10.1186/s12979-022-00288-7).

In an epidemiological study of very old Chinese adults in Hainan, SUN et al. (2022) found that depressive symptoms, assessed according to the Geriatric Depression Scale, were present in women of more advanced age (99 yrs average), and were associated with higher IgA serum levels, together with smaller but significant decreases in haemoglobin, IgM and C3 levels (https://doi.org/10.1186/s12979-022-00283-y). This finding deserves further scrutiny for a mechanistic explanation.

Neuroinflammation in the pathogenesis of neurodegenerative diseases

Neuroinflammation is also key to the pathogenesis of neurodegenerative diseases [10]. Natural antibodies (nAbs) against aggregation-prone proteins have been found in both healthy subjects as well as in patients with neurodegenerative disorders. Here, PAGANELLI et al. (2023) measured nAbs to Aβ protein in a group of Italian patients with Alzheimer’s Disease (AD), vascular dementia, non-demented patients with Parkinson’s Disease (PD) and healthy elderly controls (https://immunityageing.biomedcentral.com/articles/https://doi.org/10.1186/s12979-023-00336-w). The Aβ antibody levels in AD were similar to age- and sex-matched controls, but significantly reduced in PD. This study may identify patients that could be more prone to amyloid aggregation.

Peripheral evidence of inflammatory processes may shed light on localized neuroinflammation, as COSTANTINI et al. (2023) propose in their paper on different gene expression of acetylcholine receptor (AChR) subunits in blood mononuclear cells (https://doi.org/10.1186/s12979-023-00329-9). Some types were underrepresented in leukocytes from patients with Lewy body-type dementia and Alzheimer disease, but with different patterns, as also the case for inflammatory cytokines which were more highly expressed but at different levels and without association with AChRs – despite reports that AChR7 and AChR2/4 suppress the release of proinflammatory cytokines when activated.

The blood-brain interaction was also investigated by LI et al. (2023) in mice transgenic for APP/PS1, and in a parabiotic model with wild-type mice. They studied the effects of high levels of amyloid Aβ on circulating macrophages (https://doi.org/10.1186/s12979-023-00366-4) and found that high plasma levels of Aβ1–42 play a biphasic role, i.e. inhibiting effects on peripheral pro-inflammatory macrophages in the early stage of the model, but promoting inflammation in the late stage. The effects are suggested to be mediated by myeloid-derived suppressor cells in the spleen and myeloid precursors in the bone marrow, adding more layers of complexity.

Signatures of pain arising from nerve injuries are generally associated with changes in cell numbers, trafficking, and immune phenotypes within dorsal root ganglia (DRG). In this context, CHOCONTA et al. (2023) investigated neuroimmune processes involved in the DRG of Fabry disease (https://immunityageing.biomedcentral.com/articles/https://doi.org/10.1186/s12979-023-00346-8). Pain in Fabry disease (FD) is generally accepted to result from neuronal damage in the peripheral nervous system because of excess lipid storage caused by alpha-galactosidase A (α-Gal A) deficiency. Using a mouse model of FD, they report significant alterations of lysosomal signatures in sensory neurons and of macrophage morphology and phenotypes in the DRG. The changes in macrophage morphology are suggestive of premature ageing, and these cells could be targeted in better therapies.

Interventions to mitigate age-related neuroinflammation

This Topical Collection includes articles exploring the beneficial effects of interventions aimed to mitigate neuroinflammation. GONG et al. (2023) investigated the molecular mechanisms by which glycyrrhizic acid (GA), a saponin compound often used as a flavouring agent, improves cognition in mice through immunomodulation (https://immunityageing.biomedcentral.com/articles/https://doi.org/10.1186/s12979-023-00337-9). Single-cell sequencing data of PBMCs revealed that GA reduced age-related increases in myeloid cells and increased numbers of lymphoid lineage subpopulations. In vitro, GA significantly promoted the differentiation of hematopoietic stem cells toward lymphoid lineages, of note CD8+ T cells. Moreover, GA inhibited the differentiation of CD4+ T cells and myeloid (CD11b+) cells by binding to S100 calcium-binding protein 8 (S100A8) protein.

The mechanism of beneficial effects of exercise on the brain was investigated by HAN et al. (2023) by exploring the phenotypic and functional changes induced in microglia by the metabolite product of exercise, lactate. Activated microglia exhibit abnormal morphology and proliferation and release inflammatory and bioactive molecules, which may damage neurons; these investigators found that addition of lactate, through a lactate “timer”, accelerated the upregulation of homeostatic genes producing an anti-inflammatory reparative phenotype transition of microglia in mice pretreated with aluminium-D-Galactose which induces an Alzheimer-like syndrome. Induction of Arginase-1 reflected the initiation of a reparative phenotype through lactylation of histone H3 in brains of mice after exercise training, which also demonstrated improved cognitive function and less neuronal loss in the brain.

ZAMORANO et al. (2023) showed that treatment of 9-month-old male mice with the chemotherapeutic agent cisplatin causes cognitive defects that are associated with the formation of tau deposits in the hippocampus. Nasal administration of mesenchymal stromal cells (MSC) at 48 and 96 h after cisplatin prevented formation of tau deposits and normalized syndecan-2 and GFAP expression (https://doi.org/10.1186/s12979-023-00328-w). Cisplatin-induced tau cluster formation was associated with reduced executive functioning and working/spatial memory; nasal administration of MSC prevented these cognitive defects. Notably, delayed MSC administration (one month after cisplatin) also prevented tau cluster formation and cognitive alterations. Developing nasal MSC administration for treatment of accelerated brain aging and cognitive problems in cancer survivors should be feasible and would greatly improve their quality of life.

Neuroinflammation also has a key role in infection-induced neurological injury, particularly in older adults with increased incidence of sepsis following CNS infection. Brain tissue-resident memory T cells (bTRM) are recruited during CNS infection and promote pathogen control as well as deleterious inflammation. Here, CASSIDY et al. (2022) explored the anti-inflammatory actions of the microRNA miR-155 during neuroinvasive infection of mice with Listeria monocytogenes (https://immunityageing.biomedcentral.com/articles/; https://doi.org/10.1186/s12979-022-00281-0). Notably, anti-miR-155 treatment reduced the accumulation of brain myeloid cells in aged mice after infection, whereas CD8+ bTRM were unaffected.

In a transgenic RNAi screen using Drosophila as a model, YUE et al. (2023) report that knockdown of Dsor1 (the Drosophila MAPK kinase dMEK) suppressed protein inclusion containing TAR DNA-binding protein of 43 kDa (TDP-43) toxicity, without altering TDP-43 phosphorylation or protein levels (https://doi.org/10.1186/s12979-023-00354-8). TDP-43 is an important DNA/RNA-binding protein that is associated with age-related neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal dementia. Further investigation revealed that the Dsor1 downstream gene rl (dERK) was abnormally upregulated in TDP-43 flies, and neuronal overexpression of dERK induced profound upregulation of antimicrobial peptides (AMPs). This induced immune overactivation in TDP-43 flies, which was suppressed by downregulation of the MEK/ERK pathway in TDP-43 fly neurons. Neuronal knockdown of Dnr1, a negative regulator of the Drosophila immune deficiency (IMD) pathway, activated innate immunity and boosted AMP expression independent of regulation by the MEK/ERK pathway. An FDA-approved MEK inhibitor (trametinib) markedly suppressed immune overactivation, alleviated motor deficits and prolonged the lifespan of TDP-43 flies, but did not exhibit such features in either AD or spinocerebellar ataxia type 3 (SCA3) fly models. This study sheds new light on the pathogenesis of TDP-43 neurological damage.

MÜLLER and DI BENEDETTO (2023) review neuroimmune interactions in the aged brain and highlight the impact of COVID-19 on the functional systems already modulated by immunosenescence and neuroinflammation (https://immunityageing.biomedcentral.com/articles/https://doi.org/10.1186/s12979-023-00341-z). They discuss the potential neuroimmune interactions involved in COVID-19 sequelae, reviewing mechanisms and biological factors that may contribute to persisting long COVID conditions. The main biological mechanisms involved with long COVID are discussed as well as various interventional options (e.g. nutritional, exercise and behavioural) that may mitigate the neuroimmune activation associated with unbalanced inflammatory responses.

In a comprehensive review, SAHEBNASAGH et al. (2022) describe the concept of neurohormesis and apply it to herbal remedies and plant-derived drugs used to alleviate or cure the symptoms of neurological diseases (https://doi.org/10.1186/s12979-022-00292-x). These include both neurodegenerative (Alzheimer, Parkinson) as well as other neurological disorders such as autism and Huntington’s disease. The reader is taken through neurohormetic herbal medicines (i.e. the hormetic properties of phytochemicals used to treat neurological disorders) for aging, neuroprotection, memory enhancement, and the effects of these phytochemicals on the immune system and the mitochondria functions.

The studies described in the 17 papers in this Topical Collection give an all-encompassing view of the complex relationships between immune system changes with ageing, and several diseases of the central nervous system, as well as novel potential targets able to influence the progression of neurological impairment.

Not applicable.

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The Authors are indebted to Ms. Britta Mueller for precious help with manuscript handling during the review process and editorial work for the Topical Collection.

No funds were made available for this publication.

Authors and Affiliations

  1. Laboratory of Immunobiology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil

    Moisés E. Bauer

  2. Department of Immunology, University of Tübingen, Tübingen, Germany

    Graham Pawelec

  3. Health Sciences North Research Institute, Sudbury, ON, Canada

    Graham Pawelec

  4. YDA-Institute of Clinical Immunotherapy and Advanced Biological Treatments, Pescara, 65121, Italy

    Roberto Paganelli

  5. Internal Medicine, UniCamillus, International Medical University in Rome, via di Sant’Alessandro 6, Rome, 00131, Italy

    Roberto Paganelli

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Contributions

M.E.B. and R.P. wrote the first draft of the editorial; G.P. provided further observations and corrections to the text; all co-authors revised the manuscript and approved the final version.

Corresponding author

Correspondence to Roberto Paganelli.

Competing interests

The Authors M.E.B. and R.P. declare they have also served as Guest Editors for this Topical Collection, and G.A. as Editor-in-Chief for this Journal.

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Bauer, M.E., Pawelec, G. & Paganelli, R. Neuroimmunology and ageing – the state of the art. Immun Ageing 21, 5 (2024). https://doi.org/10.1186/s12979-024-00411-w

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神经免疫学与老龄化--最新进展
biomedcentral.com/articles/; https://doi.org/10.1186/s12979-022-00289-6).在老龄小鼠的室管膜下区观察到了T细胞浸润。细胞-细胞相互作用分析表明,老龄小胶质细胞释放 CCL3 来招募外周 CD8 + 记忆 T 细胞。作为潜在的结果,老化的小胶质细胞改变了其表型,转为促炎状态,释放 TNF-α 上调 BEC 中 VCAM1 和 ICAM1 的表达,从而促进外周 T 细胞迁移到大脑中。体外实验显示,用老年人的 CSF 处理人类小胶质细胞时,它们也会转变为趋化表型。这项研究揭示了正常衰老过程中维持大脑平衡所涉及的神经免疫途径。正常 "中枢神经系统中免疫细胞的独特图谱是评估疾病中观察到的变化的有用指南。NEVALAINEN等人(2022年)在一项研究中提供了这一信息,该研究在55名无脑部疾病的捐献者的13个不同脑区中发现了22种细胞类型,代表了自然和适应性免疫细胞。免疫细胞的比例是通过评估多个基因特征并使用细胞测量工具 CIBERSORTx 进行分析后确定的,从而利用 547 个特征基因的表达水平确定了细胞亚型 (https://doi.org/10.1186/s12979-022-00302-y)。衰老的影响是增加了先天性免疫细胞(主要是单核细胞)的存在,减少了不同脑区的所有适应性免疫细胞。与年龄相关的浸润性免疫细胞组成的差异与在组织稳态中的作用一致。这种与性别相关的认知偏差包括影响人们记忆和解释信息的消极思维模式。认知偏差受海马体神经发生和神经炎症的影响。鉴于认知偏差与神经发生和炎症的关系,HODGES 等人(2022 年)研究了认知偏差、海马的神经发生以及雌雄大鼠腹侧海马(HPC)和基底外侧杏仁核(BLA)的细胞因子水平与整个生命周期的关系(https://immunityageing.biomedcentral.com/articles/; https://doi.org/10.1186/s12979-022-00299-4)。在进行认知偏差测试后,雄性大鼠在青春期腹侧海马区的炎性细胞因子含量高于雌性大鼠。在青壮年时期,雌性大鼠比雄性大鼠在腹腔脂肪细胞中含有更多的 IFN-γ、IL-1β、IL-4、IL-5 和 IL-10。中年大鼠两个区域中的IL-13、TNF-α和CXCL1含量均高于年轻组。在认知偏差测试后,青春期雄性大鼠的海马神经发生率高于青春期雌性大鼠。年轻雄性背侧海马体的神经发生与负面认知偏差呈负相关。综上所述,这些结果表明,大脑中的负性认知偏差、海马神经发生和炎症之间的关联因年龄和性别而异。全世界的肥胖率正在显著上升。肥胖会导致许多并发症,如增加老年人认知能力下降的风险。免疫系统的一些变化,如炎症和免疫衰老,在肥胖和衰老中都很常见,可能会影响认知能力的下降。因此,整个生命周期中免疫系统的变化可能会影响肥胖如何影响神经炎症以及与之相关的认知能力下降。为了更好地理解这种关系,HENN 等人(2022 年)使用高脂饮食(HFD)肥胖小鼠模型(https://immunityageing.biomedcentral.com/articles/; https://doi.org/10.1186/s12979-022-00323-7)研究了与认知变化相关的代谢和炎症特征。摄入高脂饮食的小鼠海马基因表达发生了与年龄相关的显著变化。高脂饮食在年轻组和中年组都造成了代谢异常表型。然而,年龄越大,高密度脂蛋白饮食对认知和神经炎症的影响就越大,海马炎症基因的表达也随之改变。总之,这些数据表明,肥胖(高频分解膳食)会促进大脑过早老化表型,这表明了炎症和免疫衰老。刘(LIU)等人(2023 年)对一个由 2944 人组成的队列进行了为期 2 年的跟踪研究,评估了饮食对认知障碍的促炎或抗炎作用;纵向研究显示,饮食炎症指数较高的男性认知能力下降幅度增大。巢式病例对照研究进一步证实了这一点。
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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
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