Promoting biocompatibility of titanium by facile fabrication of phase-transited lysozyme induced hydroxyapatite coating

IF 7.5 Q1 CHEMISTRY, PHYSICAL

Applied Surface Science Advances Pub Date : 2024-01-09 DOI:10.1016/j.apsadv.2023.100568

Qian Lan , Hengjun Zhang , Xin Xiao , Xueting Bi , Jifeng Xiong

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Abstract

In this study, phase-transited lysozyme (PTL) induced Ca₁₀(PO₄)₆(OH)₂ (PTL-HA) coating was applied to the 3D-printed titanium surface for improving bioactivity. The morphology and phase of the coating were analyzed by EDS, SEM, XRD, and XPS, while biocompatibility was investigated in vitro. The observation from SEM showed that a uniform coating with the presence of spheric-like and plate-shaped crystals was covered on the titanium. The main composition of the coating was Ca₁₀(PO₄)₆(OH)₂. More importantly, the in vitro results showed the PTL-HA coating could upregulate the expression of osteogenic-related genes. Therefore, it is considered that the phase-transited lysozyme-induced hydroxyapatite film was a promising, rapid, low-cost, and green route to improve the bioactivity of a bone implant.

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通过简便地制造相变溶菌酶诱导羟基磷灰石涂层促进钛的生物相容性

本研究将相变溶菌酶（PTL）诱导的 Ca10(PO4)6(OH)2（PTL-HA）涂层应用于三维打印钛表面，以提高其生物活性。通过 EDS、SEM、XRD 和 XPS 分析了涂层的形态和相位，并在体外研究了其生物相容性。扫描电镜的观察结果表明，钛上覆盖了一层均匀的涂层，其中存在球状和板状晶体。涂层的主要成分是 Ca10(PO4)6(OH)2。更重要的是，体外实验结果表明，PTL-HA 涂层能上调成骨相关基因的表达。因此，相变溶菌酶诱导的羟基磷灰石薄膜被认为是提高骨植入物生物活性的一种可行、快速、低成本和绿色的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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