Structural Changes in Depressed Patients Directly After Treatment With Electroconvulsive Therapy and 3 Months Later.

IF 1.8 4区医学 Q3 BEHAVIORAL SCIENCES

Journal of Ect Pub Date : 2024-09-01 Epub Date: 2023-12-28 DOI:10.1097/YCT.0000000000000985

Stevie Jaarsveld, Peter Mulders, Indira Tendolkar, Philip van Eijndhoven

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引用次数: 0

Abstract

Objectives: It is assumed that neuroplasticity plays a central role in the effect of electroconvulsive therapy (ECT) on patients with major depressive disorder. We carried out an explorative study to map out the extent in which gray matter volume changes could be found directly after ECT treatment and after follow-up.

Methods: Initially, 12 patients with treatment-resistant depression were recruited from the Radboud Medical Center. Magnetic resonance imaging scans were conducted at the following 3 time points: before ECT (n = 12), after ECT (n = 10), and at 3-month follow-up (n = 8). Subcortical volume, hippocampal subfield volume, and cortical thickness were analyzed using FreeSurfer.

Results: The extensive, generalized changes in gray matter volume are largely transient after treatment with ECT, with the noted exceptions being a sustained increase in volume of the right amygdala and a part of the left cornu ammonis. Post hoc testing revealed no significant correlation with clinical response.

Discussion: Our results suggest that the neuroplastic effects of ECT may not be mediators of clinical response and could be transient epiphenomena.

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抑郁症患者在接受电休克疗法治疗后和三个月后的结构变化

目的：据推测，神经可塑性在电休克疗法（ECT）对重度抑郁症患者的影响中起着核心作用。我们开展了一项探索性研究，以了解电休克疗法治疗后和随访后灰质体积变化的程度：方法：最初，我们从拉德布德医学中心招募了 12 名耐药抑郁症患者。在以下3个时间点进行了磁共振成像扫描：ECT治疗前（12人）、ECT治疗后（10人）和3个月随访时（8人）。使用FreeSurfer对皮层下体积、海马子野体积和皮层厚度进行了分析：结果：经电痉挛疗法治疗后，灰质体积的广泛、普遍变化基本上是短暂的，但右侧杏仁核和左侧粟粒体的部分体积持续增加。事后测试显示，这与临床反应无明显关联：讨论：我们的研究结果表明，电痉挛疗法的神经可塑性效应可能不是临床反应的媒介，而可能是短暂的附带现象。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Ect 医学-行为科学

CiteScore

3.70

自引率

20.00%

发文量

154

审稿时长

6-12 weeks

期刊介绍： The Journal of ECT covers all aspects of contemporary electroconvulsive therapy, reporting on major clinical and research developments worldwide. Leading clinicians and researchers examine the effects of induced seizures on behavior and on organ systems; review important research results on the mode of induction, occurrence, and propagation of seizures; and explore the difficult sociological, ethical, and legal issues concerning the use of ECT.