The Role of Osteocytes in Pre-metastatic Niche Formation.

IF 4.3 2区医学

Current Osteoporosis Reports Pub Date : 2024-02-01 Epub Date: 2024-01-10 DOI:10.1007/s11914-023-00857-9

Emma N Briggs, Maureen E Lynch

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引用次数: 0

Abstract

Purpose of review: The formation of a pre-metastatic niche (PMN), in which primary cancer cells prime the distant site to be favorable to their engraftment and survival, may help explain the strong osteotropism observed in multiple cancers, such as breast and prostate. PMN formation, which includes extracellular matrix remodeling, increased angiogenesis and vascular permeability, enhanced bone marrow-derived cell recruitment and immune suppression, has mostly been described in soft tissues. In this review, we summarize current literature of PMN formation in bone. We also present evidence of a potential role for osteocytes to be the primary mediators of PMN development.

Recent findings: Osteocytes regulate the bone microenvironment in myriad ways beyond canonical bone tissue remodeling, including changes that contribute to PMN formation. Perilacunar tissue remodeling, which has been observed in both bone and non-bone metastatic cancers, is a potential mechanism by which osteocyte-cancer cell signaling stimulates changes to the bone microenvironment. Osteocytes also protect against endothelial permeability, including that induced by cancer cells, in a loading-mediated process. Finally, osteocytes are potent regulators of cells within the bone marrow, including progenitors and immune cells, and might be involved in this aspect of PMN formation. Osteocytes should be examined for their role in PMN formation.

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骨细胞在转移前龛位形成中的作用

综述的目的：转移前生态位（PMN）的形成有助于解释在乳腺癌和前列腺癌等多种癌症中观察到的强烈的向骨性。PMN的形成包括细胞外基质重塑、血管生成和血管通透性增加、骨髓源性细胞募集增强和免疫抑制，这主要是在软组织中描述的。在本综述中，我们总结了目前有关骨中 PMN 形成的文献。我们还提出了一些证据，证明骨细胞可能是 PMN 形成的主要介质：最新发现：除了典型的骨组织重塑外，骨细胞还以多种方式调节骨微环境，包括有助于 PMN 形成的变化。在骨癌和非骨转移癌中都观察到了周组织重塑，这是骨细胞-癌细胞信号刺激骨微环境变化的潜在机制。骨细胞还能在负载介导的过程中防止内皮细胞渗透，包括癌细胞诱导的内皮细胞渗透。最后，骨细胞是骨髓内细胞（包括祖细胞和免疫细胞）的有效调节器，可能参与了 PMN 形成的这一方面。应研究骨细胞在 PMN 形成中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Osteoporosis Reports ENDOCRINOLOGY & METABOLISM-

CiteScore

8.40

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.