Effects of swimming training in hot and cold temperatures combined with cinnamon supplementation on HbA1C levels, TBC1D1, and TBC1D4 in diabetic rats.

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Seyed Morteza Tayebi, Amir Hossein Nouri, Bakhtyar Tartibian, Somayeh Ahmadabadi, Aref Basereh, Iman Jamhiri
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引用次数: 0

Abstract

Aims: Diabetes is one of the main causes of mortality in developing countries. Performing physical activity in various ways and different environments using herbal supplements can be used as a non-pharmacological solution to prevent and improve diabetes. Hence, this study aimed to investigate the effects of eight weeks of cold water swimming exercise training combined with cinnamon supplementation on HbA1C (Hemoglobin A1c) levels, TBC1D1 (TBC1 domain family member 1), and TBC1D4 (TBC1 Domain Family Member 4) in diabetic rats.

Materials and methods: Ninety-one rats (n = 78 diabetic, n = 13 healthy) were divided into seven groups (n = 13 per group): (1) healthy control (HC), (2) diabetic control (DC), (3) swimming training in cold water (5 °C) (S5), (4) swimming training in cold water (5 °C) with a cinnamon supplementation (200 mg/kg body weight) (S5+Ci), (5) swimming training in warm water (36-35 °C) (S35), (6) swimming training in warm water (35-36 °C) with a cinnamon supplementation (S35+Ci), and (7) a cinnamon supplementation only (Ci). To evaluate the hypothesis, a one-way ANOVA and Tukey's post hoc test were used.

Results: Findings showed that the TBC1D1 and TBC1D4 levels in the DC and S35 groups were higher than in the HC group (p < 0.001). Also, swimming training in cold water (5 °C) with cinnamon supplementation (S5+Ci) decreased the level of TBC1D1, TBC1D4, HbA1c, and glucose compared to other groups (p < 0.05).

Conclusions: The study revealed that the combination of swimming training in cold water and cinnamon consumption led to a significant reduction in TBC1D1, TBC1D4, and HbA1c. Therefore, this non-traditional exercise approach coupled with cinnamon supplementation can be considered an effective method for improving insulin sensitivity, fasting blood glucose, and HbA1c levels and is proposed as an optimal method to improve glucose indices.

Abstract Image

在高温和低温下进行游泳训练并补充肉桂对糖尿病大鼠 HbA1C 水平、TBC1D1 和 TBC1D4 的影响
目的:在发展中国家,糖尿病是导致死亡的主要原因之一。利用草药补充剂在不同环境中以不同方式进行体育锻炼,可作为预防和改善糖尿病的非药物疗法。因此,本研究旨在调查八周冷水游泳运动训练结合肉桂补充剂对糖尿病大鼠 HbA1C(血红蛋白 A1c)水平、TBC1D1(TBC1 领域家族成员 1)和 TBC1D4(TBC1 领域家族成员 4)的影响:将 91 只大鼠(n = 78 只糖尿病大鼠,n = 13 只健康大鼠)分为 7 组(每组 n = 13 只):(1)健康对照组(HC);(2)糖尿病对照组(DC);(3)冷水(5 °C)游泳训练组(S5);(4)补充肉桂(200 毫克/千克体重)的冷水(5 °C)游泳训练组(S5+Ci)、(5)在温水(36-35 °C)中进行游泳训练(S35);(6)在温水(35-36 °C)中进行游泳训练并补充肉桂(S35+Ci);以及(7)仅补充肉桂(Ci)。为了评估假设,采用了单因素方差分析和 Tukey 后检验:结果表明,DC 组和 S35 组的 TBC1D1 和 TBC1D4 水平高于 HC 组(P 结论:DC 组和 S35 组的 TBC1D1 和 TBC1D4 水平高于 HC 组(P研究显示,冷水游泳训练与食用肉桂相结合,可显著降低 TBC1D1、TBC1D4 和 HbA1c。因此,这种非传统的运动方式与肉桂补充剂相结合可被视为改善胰岛素敏感性、空腹血糖和 HbA1c 水平的有效方法,并被建议作为改善血糖指数的最佳方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nutrition & Diabetes
Nutrition & Diabetes ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
CiteScore
9.20
自引率
0.00%
发文量
50
审稿时长
>12 weeks
期刊介绍: Nutrition & Diabetes is a peer-reviewed, online, open access journal bringing to the fore outstanding research in the areas of nutrition and chronic disease, including diabetes, from the molecular to the population level.
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