Outcomes and complications of patients with cerebral venous thrombosis: a retrospective study.

IF 1.2 4区医学 Q4 CLINICAL NEUROLOGY

Neurosciences Pub Date : 2024-01-01 DOI:10.17712/nsj.2024.1.20230050

Mosaad O Almegren, Saleh H Alharbi, Turki A Alshuaibi, Mohammed M Almansour, Khalid A Alharbi, Bader Al Rawahi, Abdulmajeed K Al Balushi, Abdulrahman A Alraizah, Farjah H Alqahtani

{"title":"Outcomes and complications of patients with cerebral venous thrombosis: a retrospective study.","authors":"Mosaad O Almegren, Saleh H Alharbi, Turki A Alshuaibi, Mohammed M Almansour, Khalid A Alharbi, Bader Al Rawahi, Abdulmajeed K Al Balushi, Abdulrahman A Alraizah, Farjah H Alqahtani","doi":"10.17712/nsj.2024.1.20230050","DOIUrl":null,"url":null,"abstract":"Objectives: To assess outcomes and complications of patients with cerebral venous thrombosis (CVT).Methods: This multicenter retrospective study was conducted at 2 health care centers in Saudi Arabia and Oman. Adult patients diagnosed with CVT in radiological imaging between 2006 and 2020 were included. Data were collected from medical records and analyzed using the software IBM® SPSS version 22. Neurological disability occurring after CVT was graded according to the modified Rankin scale (mRS).Results: The study included 103 patients, of which the majority (68%) were female. The mean age was 39.12±12.96 years. Two-thirds of patients received low-molecular-weight heparin (LMWH) in acute treatment, while 76% of discharged patients used warfarin. The majority of patients had no or mild neurological disability during follow-up, and 6 patients had an mRS score ≥3, implying significant neurological disability. There were 55 patients (52.3%) who had complications from CVT, including seizures in 17 (16.5%) patients and one mortality. Follow-up imaging of 55 patients showed complete thrombus resolution in 20 patients (36%).Conclusion: Anticoagulation is the mainstay treatment for CVT patients. Approximately half of patients experience complications. Prospective studies are needed to assess the long-term neurological outcomes in such patients.","PeriodicalId":19284,"journal":{"name":"Neurosciences","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10827010/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurosciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.17712/nsj.2024.1.20230050","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: To assess outcomes and complications of patients with cerebral venous thrombosis (CVT).

Methods: This multicenter retrospective study was conducted at 2 health care centers in Saudi Arabia and Oman. Adult patients diagnosed with CVT in radiological imaging between 2006 and 2020 were included. Data were collected from medical records and analyzed using the software IBM® SPSS version 22. Neurological disability occurring after CVT was graded according to the modified Rankin scale (mRS).

Results: The study included 103 patients, of which the majority (68%) were female. The mean age was 39.12±12.96 years. Two-thirds of patients received low-molecular-weight heparin (LMWH) in acute treatment, while 76% of discharged patients used warfarin. The majority of patients had no or mild neurological disability during follow-up, and 6 patients had an mRS score ≥3, implying significant neurological disability. There were 55 patients (52.3%) who had complications from CVT, including seizures in 17 (16.5%) patients and one mortality. Follow-up imaging of 55 patients showed complete thrombus resolution in 20 patients (36%).

Conclusion: Anticoagulation is the mainstay treatment for CVT patients. Approximately half of patients experience complications. Prospective studies are needed to assess the long-term neurological outcomes in such patients.

查看原文本刊更多论文

脑静脉血栓患者的预后和并发症：一项回顾性研究。

目的：评估脑静脉血栓形成（CVT）患者的预后和并发症：评估脑静脉血栓（CVT）患者的预后和并发症：这项多中心回顾性研究在沙特阿拉伯和阿曼的两家医疗中心进行。研究纳入了 2006 年至 2020 年期间经放射成像诊断为 CVT 的成年患者。研究人员从病历中收集数据，并使用 IBM® SPSS 22 版软件进行分析。CVT后出现的神经残疾根据改良Rankin量表（mRS）进行分级：研究共纳入 103 名患者，其中大多数（68%）为女性。平均年龄为（39.12±12.96）岁。三分之二的患者在急性期接受了低分子量肝素（LMWH）治疗，76%的出院患者使用华法林。大多数患者在随访期间无神经系统残疾或有轻度神经系统残疾，6 名患者的 mRS 评分≥3，意味着有明显的神经系统残疾。55名患者（52.3%）出现了CVT并发症，其中17人（16.5%）癫痫发作，1人死亡。55 名患者的随访成像显示，20 名患者（36%）的血栓完全消退：结论：抗凝是治疗 CVT 患者的主要方法。结论：抗凝是 CVT 患者的主要治疗方法，约有一半的患者会出现并发症。需要进行前瞻性研究，以评估此类患者的长期神经功能预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Neurosciences 医学-临床神经学

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

4.5 months

期刊介绍： Neurosciences is an open access, peer-reviewed, quarterly publication. Authors are invited to submit for publication articles reporting original work related to the nervous system, e.g., neurology, neurophysiology, neuroradiology, neurosurgery, neurorehabilitation, neurooncology, neuropsychiatry, and neurogenetics, etc. Basic research withclear clinical implications will also be considered. Review articles of current interest and high standard are welcomed for consideration. Prospective workshould not be backdated. There are also sections for Case Reports, Brief Communication, Correspondence, and medical news items. To promote continuous education, training, and learning, we include Clinical Images and MCQ’s. Highlights of international and regional meetings of interest, and specialized supplements will also be considered. All submissions must conform to the Uniform Requirements.