Qiannan Li, Yinghui Lu, Jinfeng Shang, Qi Song, Jiakang Jiao, Lei Bi, Tingyue Jiang, Xin Liu
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引用次数: 0
Abstract
Background: To explore the effect of Ganshuang granule on anti-alcoholic and anti-hangover and its potential mechanism.
Methods: SPF SD rats' drunken model and SPF Kunming mice's hangover model were used as models.
Results: Ganshuang granule could significantly reduce sleep time, the time to climb in mice, and significantly prolong the tolerance time and shorten sleep time in rats (p < 0.05). The blood ethanol concentration of rats in each administration group was lower than that in the model group at each time point (p < 0.05). Compared with the control group, the activities of ADH and ALDH in the liver of the model group were significantly decreased (p < 0.05); the content of DA and 5-HT in the striatum of the model group was significantly increased (p < 0.05); and the activity of AchE in the hippocampus was significantly decreased (p < 0.05). The above processes could be improved and regulated in the drug administration group. Compared with the control group, there was no significant difference between ADH and ALDH in the serum of the model group (p > 0.05). However, the activities of ADH and ALDH in the liver of drunk rats could be upregulated by Ganshuang granule (p < 0.05).
Conclusion: Ganshuang granule has the pharmacological effects of anti-alcoholic and anti-hangover, which is related to regulating the activities of ADH and ALDH in the liver, the contents of DA and 5-HT in striatum, and the activity of AchE in the hippocampus.
背景：探讨甘舒良颗粒的抗酒精、抗宿醉作用及其潜在机制：方法：以SPF SD大鼠醉酒模型和SPF昆明小鼠宿醉模型为研究对象，探讨甘双颗粒的抗酒精、抗宿醉作用及其潜在机制：方法：以SPF SD大鼠醉酒模型和SPF昆明小鼠宿醉模型为研究对象：结果：甘爽颗粒能明显缩短小鼠的睡眠时间和爬起时间，明显延长大鼠的耐受时间和缩短睡眠时间（P P P P P > 0.05）。但醉酒大鼠肝脏中ADH和ALDH的活性可被丹参颗粒上调（P 结论：丹参颗粒对醉酒大鼠肝脏中ADH和ALDH的活性有明显的抑制作用：甘双颗粒具有抗酒精中毒和抗宿醉的药理作用，与调节肝脏中ADH和ALDH的活性、纹状体中DA和5-HT的含量以及海马中AchE的活性有关。
期刊介绍：
The International Journal of Neuroscience publishes original research articles, reviews, brief scientific reports, case studies, letters to the editor and book reviews concerned with problems of the nervous system and related clinical studies, epidemiology, neuropathology, medical and surgical treatment options and outcomes, neuropsychology and other topics related to the research and care of persons with neurologic disorders. The focus of the journal is clinical and transitional research. Topics covered include but are not limited to: ALS, ataxia, autism, brain tumors, child neurology, demyelinating diseases, epilepsy, genetics, headache, lysosomal storage disease, mitochondrial dysfunction, movement disorders, multiple sclerosis, myopathy, neurodegenerative diseases, neuromuscular disorders, neuropharmacology, neuropsychiatry, neuropsychology, pain, sleep disorders, stroke, and other areas related to the neurosciences.
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