Effect of fasedienol (PH94B) pherine nasal spray and steroidal hormones on electrogram responses and autonomic nervous system activity in healthy adult volunteers

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Human Psychopharmacology: Clinical and Experimental Pub Date : 2024-01-09 DOI:10.1002/hup.2892

Louis Monti, Rita Hanover, Ester Salmán, Ross A. Baker, Jaakko Lappalainen, Mark Smith

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Abstract

Objective

Fasedienol (PH94B) is a pherine compound formulated as a nasal spray that is hypothesized to regulate olfactory-amygdala circuits of fear and anxiety. Fasedienol's effect on the local electrogram of nasal chemosensory neurons (EGNR) and autonomic nervous system (ANS) responses versus steroidal hormones and controls in healthy adults is reported.

Methods

Eight males and 8 females randomly received aerosolized control (propylene glycol) and study drugs (fasedienol, 17β-estradiol, progesterone, cortisol, and testosterone, 0.4 μg each in propylene glycol) onto the nasal septum mucosal lining at 30-min intervals over 2 sessions. EGNR was continuously monitored; autonomic parameters were recorded before and after administration.

Results

Fasedienol significantly increased EGNR amplitude (males: 5.0 vs. 0.6 mV, p < 0.001; females:5.7 vs. 0.6 mV, p < 0.001), and rapidly reduced respiratory rate (p < 0.05), heart rate (p < 0.01), and electrodermal activity (p < 0.05) versus control. EGNR and ANS responses after steroidal hormone administration were similar to control. 81% reported feeling less tense/more relaxed after receiving fasedienol, but not after receiving either control or steroidal hormones.

Conclusions

Intranasal fasedienol, but not control or steroidal hormones, activated EGNR and rapidly reduced ANS responses, consistent with sympatholytic effects. Combined with subjective reports, results suggest fasedienol may provide acute relief in anxiety conditions.

Abstract Image

查看原文本刊更多论文

法斯帝诺（PH94B）菲林鼻喷雾剂和类固醇激素对健康成年志愿者的电图反应和自主神经系统活动的影响。

研究目的Fasedienol (PH94B)是一种鼻喷雾剂，据推测是一种能调节恐惧和焦虑的嗅觉-杏仁核回路的菲林化合物。本研究报告了 Fasedienol 与类固醇激素和对照组相比，对健康成年人鼻化学感觉神经元局部电图（EGNR）和自律神经系统（ANS）反应的影响：方法：8 名男性和 8 名女性随机接受对照组（丙二醇）和研究药物（雌二醇、17β-雌二醇、孕酮、皮质醇和睾酮，各 0.4 μg，含在丙二醇中）在鼻中隔粘膜上的喷雾，每次间隔 30 分钟，共 2 次。连续监测 EGNR；记录用药前后的自律神经参数：结果：法塞西诺能明显增加 EGNR 波幅（男性：5.0 vs. 0.6 mV, p 结论：法塞西诺能明显增加 EGNR 波幅（男性：5.0 vs. 0.6 mV, p鼻内注射法塞地诺而非对照组或类固醇激素可激活 EGNR 并迅速降低自律神经系统的反应，这与交感溶解作用一致。结合主观报告，结果表明法塞地诺尔可急性缓解焦虑状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Psychopharmacology: Clinical and Experimental 医学-精神病学

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Human Psychopharmacology: Clinical and Experimental provides a forum for the evaluation of clinical and experimental research on both new and established psychotropic medicines. Experimental studies of other centrally active drugs, including herbal products, in clinical, social and psychological contexts, as well as clinical/scientific papers on drugs of abuse and drug dependency will also be considered. While the primary purpose of the Journal is to publish the results of clinical research, the results of animal studies relevant to human psychopharmacology are welcome. The following topics are of special interest to the editors and readers of the Journal: -All aspects of clinical psychopharmacology- Efficacy and safety studies of novel and standard psychotropic drugs- Studies of the adverse effects of psychotropic drugs- Effects of psychotropic drugs on normal physiological processes- Geriatric and paediatric psychopharmacology- Ethical and psychosocial aspects of drug use and misuse- Psychopharmacological aspects of sleep and chronobiology- Neuroimaging and psychoactive drugs- Phytopharmacology and psychoactive substances- Drug treatment of neurological disorders- Mechanisms of action of psychotropic drugs- Ethnopsychopharmacology- Pharmacogenetic aspects of mental illness and drug response- Psychometrics: psychopharmacological methods and experimental design