Potential of Nanocarrier-Associated Approaches for Better Therapeutic Intervention in the Management of Glioblastoma.

IF 1.6 4区 医学 Q4 BIOCHEMICAL RESEARCH METHODS
Assay and drug development technologies Pub Date : 2024-02-01 Epub Date: 2024-01-09 DOI:10.1089/adt.2023.073
Vikram, Shobhit Kumar, Javed Ali, Sanjula Baboota
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引用次数: 0

Abstract

Glioblastoma, commonly known as glioblastoma multiforme (GBM), is one of the deadliest and most invasive types of brain cancer. Two factors account for the majority of the treatment limitations for GBM. First, the presence of the blood-brain barrier (BBB) renders malignancy treatment ineffective, leading to recurrence without full recovery. Second, several adverse effects are associated with the drugs used in conventional GBM treatment. Recent studies have developed nanocarrier systems, such as liposomes, polymeric micelles, dendrimers, nanosuspensions, nanoemulsions, nanostructured lipid carriers, solid lipid nanocarriers, metal particles, and silica nanoparticles, which allow drug-loaded formulations to penetrate the BBB more effectively. This has opened up new possibilities for overcoming therapy issues. Extensive and methodical searches of databases such as PubMed, Science Direct, Google Scholar, and others were conducted to gather relevant literature for this work, using precise keyword combinations such as "GBM," "brain tumor," and "nanocarriers." This review provides deep insights into the administration of drugs using nanocarriers for the management of GBM and explores new advancements in nanotechnology. It also highlights how scientific developments can be explained in connection with hopeful findings about the potential of nanocarriers for the future successful management of GBM.

纳米载体相关方法在胶质母细胞瘤治疗中更好的治疗干预潜力。
胶质母细胞瘤俗称多形性胶质母细胞瘤(GBM),是最致命、侵袭性最强的脑癌之一。有两个因素造成了 GBM 治疗的大部分局限性。首先,血脑屏障(BBB)的存在使恶性肿瘤治疗无效,导致复发而无法完全康复。其次,用于传统 GBM 治疗的药物会产生一些不良反应。最近的研究开发出了纳米载体系统,如脂质体、聚合物胶束、树枝状分子、纳米悬浮液、纳米乳液、纳米结构脂质载体、固体脂质纳米载体、金属颗粒和二氧化硅纳米颗粒,这些载体能使药物配方更有效地穿透 BBB。这为克服治疗问题提供了新的可能性。为了收集这项工作的相关文献,我们使用了 "GBM"、"脑肿瘤 "和 "纳米载体 "等精确的关键词组合,对PubMed、Science Direct、Google Scholar等数据库进行了广泛而有条理的搜索。这篇综述深入探讨了利用纳米载体给药治疗 GBM 的方法,并探讨了纳米技术的新进展。它还强调了如何结合纳米载体在未来成功治疗 GBM 的潜力这一充满希望的发现来解释科学的发展。
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来源期刊
Assay and drug development technologies
Assay and drug development technologies 医学-生化研究方法
CiteScore
3.60
自引率
0.00%
发文量
33
审稿时长
>12 weeks
期刊介绍: ASSAY and Drug Development Technologies provides access to novel techniques and robust tools that enable critical advances in early-stage screening. This research published in the Journal leads to important therapeutics and platforms for drug discovery and development. This reputable peer-reviewed journal features original papers application-oriented technology reviews, topical issues on novel and burgeoning areas of research, and reports in methodology and technology application. ASSAY and Drug Development Technologies coverage includes: -Assay design, target development, and high-throughput technologies- Hit to Lead optimization and medicinal chemistry through preclinical candidate selection- Lab automation, sample management, bioinformatics, data mining, virtual screening, and data analysis- Approaches to assays configured for gene families, inherited, and infectious diseases- Assays and strategies for adapting model organisms to drug discovery- The use of stem cells as models of disease- Translation of phenotypic outputs to target identification- Exploration and mechanistic studies of the technical basis for assay and screening artifacts
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