Risk of Neuropsychiatric Symptoms Among People Who Develop Cognitive Impairment With and Without a History of Post-traumatic Stress Disorder.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Alzheimer Disease & Associated Disorders Pub Date : 2024-01-01 Epub Date: 2023-12-28 DOI:10.1097/WAD.0000000000000594

Jaime Perales-Puchalt, Kathryn Gauthreaux, Jason D Flatt, Oanh L Meyer, Walter A Kukull

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引用次数: 0

Abstract

We aimed to prospectively assess the change in neuropsychiatric symptoms among people who develop cognitive impairment and have a history of post-traumatic stress disorder (PTSD). We analyzed longitudinal data from the National Alzheimer's Coordinating Center Unified Data Set (March 2015 to December 2021). Analyses included individuals who were cognitively normal and who had nonmissing assessment of PTSD at the initial visit and had at least 1 follow-up visit with cognitive impairment. We compared the difference in the mean neuropsychiatric symptom score at the first Unified Data Set visit versus the first visit with a Clinical Dementia Rating of 0.5 between those with and without a history of PTSD. The mean neuropsychiatric symptom score change did not differ between those with and without a history of PTSD (1.06 vs. 0.77, respectively; P =0.79). The null results found in this study warrant future research. Several methodological limitations might explain these results.

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有创伤后应激障碍史和无创伤后应激障碍史的认知障碍患者出现神经精神症状的风险。

我们旨在前瞻性地评估出现认知障碍并有创伤后应激障碍（PTSD）病史的人的神经精神症状的变化。我们分析了国家阿尔茨海默氏症协调中心统一数据集（2015 年 3 月至 2021 年 12 月）中的纵向数据。分析对象包括认知能力正常、初次就诊时创伤后应激障碍评估无遗漏且至少有一次随访出现认知障碍的患者。我们比较了有创伤后应激障碍病史和无创伤后应激障碍病史者在首次统一数据集就诊时的平均神经精神症状评分与临床痴呆评级为 0.5 的首次就诊时的平均神经精神症状评分之间的差异。有创伤后应激障碍病史和无创伤后应激障碍病史者的平均神经精神症状评分变化没有差异（分别为 1.06 vs. 0.77；P=0.79）。本研究发现的无效结果值得在未来进行研究。一些方法上的局限性可能是造成这些结果的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.