Pericyte derivation and transplantation for blood-CNS barrier reconstitution in CNS disorders

IF 2 Q3 NEUROSCIENCES

IBRO Neuroscience Reports Pub Date : 2024-01-03 DOI:10.1016/j.ibneur.2023.12.007

Hyun Woo Kim , Kenneth Lap Kei Wu , Kin-Wai Tam , Ying-Shing Chan , Daisy Kwok-Yan Shum

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Abstract

Disruption of the blood-central nervous system barrier (BCB) is increasingly recognized as a pathological factor in diseases and trauma of the central nervous system. Despite the neuropathological impact, current treatment modalities do not target the BCB; strategies to reconstitute the impaired BCB have been restricted to nutritional and dietary remedies. As an integral cell type in the neurovascular unit, pericytes are crucial to the development, maintenance, and repair of the BCB. As such, pericytes are well poised as cellular agents for reconstitution of the impaired BCB. Here, we summarize recent revelations regarding the role of BCB disruption in diseases and trauma of the central nervous system and highlight how pericytes are harnessed to provide targeted therapeutic effect in each case. This review will also address how recent advances in pericyte derivation strategies can serve to overcome practical hurdles in the clinical use of pericytes.

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用于中枢神经系统疾病的血-中枢神经系统屏障重建的周细胞衍生和移植

血液-中枢神经系统屏障（BCB）的破坏越来越被认为是中枢神经系统疾病和创伤的病理因素之一。尽管对神经病理有影响，但目前的治疗方法并不针对血液-中枢神经系统屏障；重建受损的血液-中枢神经系统屏障的策略仅限于营养和饮食疗法。作为神经血管单元中不可或缺的细胞类型，周细胞对 BCB 的发育、维持和修复至关重要。因此，周细胞完全可以作为重建受损 BCB 的细胞制剂。在此，我们总结了最近有关中枢神经系统疾病和创伤中 BCB 破坏作用的最新发现，并重点介绍了如何利用周细胞在每种情况下提供有针对性的治疗效果。本综述还将探讨周细胞衍生策略的最新进展如何有助于克服周细胞临床应用中的实际障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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