Microbial cell factories for bio-based isoprenoid production to replace fossil resources

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Opinion in Systems Biology Pub Date : 2024-01-03 DOI:10.1016/j.coisb.2023.100502

Min-Kyoung Kang , Sang-Hwal Yoon , Moonhyuk Kwon , Seon-Won Kim

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引用次数: 0

Abstract

Concerns about environmental issues and limited fossil resources have increased interest and efforts in developing sustainable production of bio-based chemicals and fuels using microorganisms. Advanced metabolic engineering has developed microbial cell factories (MCFs) with the support of synthetic biology and systems biology. Isoprenoids are one of the largest classes of natural products and possess many practical industrial applications. However, it is challenging to meet the market demand for isoprenoids because of the current inefficient and unsustainable strategies for isoprenoid production such as chemical synthesis and plant extraction. Therefore, many efforts have been made to build isoprenoid-producing MCFs by applying metabolic engineering strategies, biological devices, and machinery from synthetic biology and systems biology. This review introduces recent studies of strain engineering and applications of biological tools and systems for developing isoprenoid MCFs. In addition, we also reviewed the isoprenoid fermentation strategies that lead to the best performance of isoprenoid-producing MCFs.

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用于生产生物基异戊二烯以替代化石资源的微生物细胞工厂

对环境问题和有限化石资源的关注，提高了人们对利用微生物开发可持续生产生物基化学品和燃料的兴趣和努力。在合成生物学和系统生物学的支持下，先进的代谢工程开发出了微生物细胞工厂（MCF）。异戊烯类化合物是最大类的天然产品之一，具有许多实际的工业应用。然而，由于目前的异戊烯类化合物生产策略（如化学合成和植物提取）效率低下且不可持续，因此要满足市场对异戊烯类化合物的需求具有挑战性。因此，人们已经做出许多努力，通过应用合成生物学和系统生物学中的代谢工程策略、生物装置和机器来构建生产异戊二烯的 MCF。本综述介绍了最近在开发异戊二烯 MCFs 的菌株工程和生物工具及系统应用方面的研究。此外，我们还综述了能使生产异戊烯类化合物的 MCF 达到最佳性能的异戊烯类化合物发酵策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Systems Biology Mathematics-Applied Mathematics

CiteScore

7.10

自引率

2.70%

发文量

期刊介绍： Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution